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phthalimidine

structure given in first source

Also Known As:

isoindolinone; 1H-Isoindol-1-one, 2,3-dihydro-

Networked: 12 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phthalic Acids: 1
      - Phthalimides: 12
        phthalimidine: 12
- Imides: 79
  - Phthalimides: 12
    - phthalimidine: 12
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoindoles: 18
      - Phthalimides: 12
        phthalimidine: 12

Experts

1.	Chiang, Yung-Hsiao: 1 article (04/2021)
2.	Gil, Jung-Eun: 1 article (04/2021)
3.	Greig, Nigel H: 1 article (04/2021)
4.	Han, Baek-Soo: 1 article (04/2021)
5.	Hoffer, Barry J: 1 article (04/2021)
6.	Hsueh, Shih Chang: 1 article (04/2021)
7.	Hwang, Inho: 1 article (04/2021)
8.	Kim, Dong Seok: 1 article (04/2021)
9.	Kim, Yu Kyung: 1 article (04/2021)
10.	Luo, Weiming: 1 article (04/2021)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2016 - "Additionally 3-aryl 3-hydroxy isoindolinone derivatives, which exhibit anti-tumor activity, can be accessed via a tandem reaction. " 08/15/2019 - "The current work confirmed that installing thioether moiety at the 4-position of isoindolinone is an effective strategy for identifying new promising lenalidomide analogs with anti-tumor activities in preclinical study." 11/01/2017 - "In current study, antitumor activity of two series of the newly synthesized spiropyrroloquinoline isoindolinone and spiropyrroloquinoline aza-isoindolinone scaffolds was evaluated against three human breast normal and cancer cell lines (MCF-10A, MCF-7 and SK-BR-3) and compared with cytotoxicity values of doxorubicin and colchicine as the standard drugs. "
2.	Coronary Occlusion 08/01/1986 - "The effects of 2 specific bradycardic agents, AQ-A39 [5,6-dimethoxy-2-[3-([alpha-(3,4-dimethoxy)phenylethyl]methyl-amino) propyl]phthalimidine hydrochloride] and AQ-AH 208 [3,4-dihydro-6,7-dimethoxy-2-]3-[(2-[3, 4-dimethoxy-phenyl)-ethyl]-aminoethyl]propyl[-1(2H)isoquinone] were evaluated for their effects on subendocardial segment shortening (% SS) as measured by sonomicrometry and regional myocardial blood flow (radioactive microspheres) in anesthetized dogs subjected to a 15 min left anterior descending coronary occlusion followed by 3 hr of reperfusion. "
3.	Psychotic Disorders (Schizoaffective Disorder) 09/15/2009 - "Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: a potential treatment for psychotic disorders."
4.	Ischemia 01/01/1985 - "[The action of a new calcium antagonist 5,6-dimethoxy-2-(3 [(alpha-(3,4-dimethoxy)-phenylethyl)methylamino] propyl)-phthalimidine hydrochloride (AQ-A 39cl) on hemodynamics and ischemia parameters in exercise ECG of patients with coronary heart disease]."
5.	Inflammation (Inflammations) 04/09/2021 - "We hence developed N-adamantyl phthalimidine (NAP) as a new thalidomide-like drug to mitigate inflammation without binding to cereblon, a key target associated with the antiproliferative, antiangiogenic, and teratogenic actions seen in this drug class. "

Related Drugs and Biologics

1.	Sulfides (Thioethers)
2.	Doxorubicin (Adriamycin)
3.	Colchicine
4.	Lenalidomide (CC 5013)
5.	Diuretics
6.	falipamil
7.	Thiazides
8.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
9.	Urea (Carbamide)
10.	Thalidomide (Thalomid)

Related Therapies and Procedures

1.	Therapeutics
2.	Microspheres (Microsphere)