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1-(1-glycero)dodeca-1,3,5,7,9-pentaene

fecapentaene mutagen of bacterial origin from human feces; structure given in first source

Also Known As:

GDPE; fecapentaene-12; 1,2-Propanediol, 3-(1,3,5,7,9-dodecapentaenyloxy)-

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - Polyenes: 164
        1-(1-glycero)dodeca-1,3,5,7,9-pentaene: 6

Experts

1.	Bekhradnia, Ahmad Reza: 1 article (01/2003)
2.	Kassaee, Mohammad Zaman: 1 article (01/2003)

Related Diseases

1.	Neoplasms (Cancer) 07/01/1993 - "Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model." 07/01/1993 - "The potential of fecapentaene-12 (FP-12) to promote tumor development was tested in a rat colon carcinogenesis model using N-methyl-N-nitrosourea (MNU) as the initiating agent. " 09/01/1988 - "The possible carcinogenic activity of synthetic fecapentaene-12 (FP-12) was studied in several mammalian test systems: (a) for carcinogenicity by intrarectal instillation in male F344/NCr rats as well as by intrarectal and subcutaneous application in male B6C3F1 mice; (b) for initiation by skin painting in female SENCAR mice followed by repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA), with 7,12-dimethylbenz[a]anthracene (DMBA) followed by TPA as positive control; (c) in a rat subcutaneous granuloma pouch assay in which mutagenicity was measured by induction of 6-thioguanine (6-TG) resistance and carcinogenicity was determined by induction of subcutaneous tumors in the pouch. "
2.	Colonic Neoplasms (Colon Cancer) 02/01/1987 - "Fecapentaene-12 (Fec-12), a compound thought to be responsible for much of the mutagenicity in fecal extracts from groups at high risk for colon cancer, was assayed for genotoxic potential in a battery of bacterial and mammalian cell short-term assays. " 01/01/2003 - "Fecapentaene-12 (Fp-12) is a potent colon cancer mutagen, which interacts with DNA. "
3.	Carcinogenesis 07/01/1993 - "Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model." 07/01/1993 - "The potential of fecapentaene-12 (FP-12) to promote tumor development was tested in a rat colon carcinogenesis model using N-methyl-N-nitrosourea (MNU) as the initiating agent. "
4.	Necrosis 10/28/1999 - "We found that in human colon epithelial cells, curcumin inhibits COX2 induction by the colon tumour promoters, tumour necrosis factor alpha or fecapentaene-12. "
5.	Granuloma 09/01/1988 - "The possible carcinogenic activity of synthetic fecapentaene-12 (FP-12) was studied in several mammalian test systems: (a) for carcinogenicity by intrarectal instillation in male F344/NCr rats as well as by intrarectal and subcutaneous application in male B6C3F1 mice; (b) for initiation by skin painting in female SENCAR mice followed by repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA), with 7,12-dimethylbenz[a]anthracene (DMBA) followed by TPA as positive control; (c) in a rat subcutaneous granuloma pouch assay in which mutagenicity was measured by induction of 6-thioguanine (6-TG) resistance and carcinogenicity was determined by induction of subcutaneous tumors in the pouch. "

Related Drugs and Biologics

1.	Thioguanine (Tioguanine)
2.	Mutagens
3.	Methylnitrosourea (N-Methyl-N-nitrosourea)
4.	DNA (Deoxyribonucleic Acid)
5.	Curcumin
6.	anthracene