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homocyclocreatine
structure given in first source
Also Known As:
1-carboxyethyl-2-imino-imidazolidine; 1-carboxyethyl-2-iminoimidazolidine; 1H-Imidazole-1-propanoic acid, 2-amino-4,5-dihydro-
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
Creatinine: 43603
homocyclocreatine: 2
Imidazolidines: 39
homocyclocreatine: 2
Related Diseases
1.
Neoplasms (Cancer)
04/20/1994 - "
Homocyclocreatine was similarly tested at concentrations from 0.2 to 20 mM against 139 tumor samples; 54 were considered evaluable.
"
04/20/1994 - "
Cyclocreatine and homocyclocreatine, at concentrations previously achieved in animal tissues (7-20 mM), had antitumor activity against 19% and 50%, respectively, of tumor samples that formed colonies in the assay.
"
04/20/1994 - "
The creatine analogues, cyclocreatine and homocyclocreatine, effectively reduced colony formation of freshly explanted human tumor cells.
"
04/20/1994 - "
The ability of cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) and homocyclocreatine (1-carboxyethyl-2-iminoimidazolidine) to inhibit the growth of cells prepared from tumor samples taken directly from patients was evaluated by quantitative measurement of colony formation in a soft-agar cell culture assay system.
"
2.
Ischemia
02/01/1983 - "
Our results suggest that in tissues of homocyclocreatine-fed animals subjected to a sudden large increase in work load or to ischemia, the residual creatine-P system would rapidly equilibrate with the adenylate system at the new lower cytosolic phosphorylation potential, whereas in the same cytosol the (homocyclocreatine-P)/(homocyclocreatine) ratio would exhibit a hysteresis or memory effect and reflect for a considerable period of time the earlier higher (ATP)/(free ADP) ratio rather than the actual lower (ATP)/(free ADP) ratio.
"
Related Drugs and Biologics
1.
Creatine
2.
Agar
3.
Adenosine Triphosphate (ATP)
4.
Adenosine Diphosphate (ADP)
5.
phosphohomocyclocreatine
6.
cyclocreatine