cycleanine

a bisbenzyl-bisisoquinoline alkaloid isolated from Chinese herb Stephania epigeae Lu; used for controlling blood pressure during anesthesia; RN refers to the R,R-isomer (cycleanine); isocycleanine is the R,S-isomer;

Also Known As:

isocycleanine; 8,11:20,23-Dietheno-1H,12H-(1,10)dioxacyclooctadecino(2,3,4-ij:11,12,13-i'j')diisoquinoline, 2,3,12a,13,14,15,24,24a-octahydro-1,13-dimethyl-5,6,17,18-tetramethoxy-, (12aR-(12aR*,24aR*))-

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - cycleanine: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - cycleanine: 4

Experts

1.	Li, Wen-Wu: 3 articles (01/2021 - 09/2016)
2.	Uche, Fidelia Ijeoma: 2 articles (01/2021 - 01/2018)
3.	McCullagh, James: 2 articles (01/2018 - 09/2016)
4.	Richardson, Alan: 2 articles (01/2018 - 09/2016)
5.	Boateng, Joshua: 1 article (01/2021)
6.	Guo, Xiaozhen: 1 article (01/2021)
7.	Horrocks, Paul: 1 article (01/2021)
8.	Huang, Chenggang: 1 article (01/2021)
9.	Okokon, Jude: 1 article (01/2021)
10.	Ullah, Imran: 1 article (01/2021)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2018 - "Our results suggest that cycleanine could be a hit compound for the future development in attacking ovarian cancer." 01/01/2018 - "These analogues showed greater potency than the unmodified cycleanine in three human ovarian cancer cell lines. " 01/01/2018 - "Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells." 01/01/2018 - "Further confocal fluorescence microscopy analysis confirmed the cellular uptake of alkaloids in ovarian cancer cells by using the unique (alkynyl)cycleanine (3) via click chemistry reaction. " 09/01/2016 - "Cycleanine, like its isomer tetrandrine isolated from T. subcordata, could be a potential new anti-ovarian cancer agent acting through the apoptosis pathway. "
2.	Neoplasms (Cancer) 10/04/2022 - "The impact of cycleanine in cancer research: a computational study." 09/01/2016 - "The IC50 of cycleanine on human normal ovarian surface epithelial cells was 35 ± 1 μM, hinting at modest selectivity toward cancer cells. "
3.	Parasitemia 01/01/2021 - "At oral doses of 25 and 50 mg/kg body weight of infected mice, cycleanine suppressed the levels of parasitemia and increased mean survival times significantly compared to those of the control groups. "
4.	Malaria 01/01/2021 - "medicinal plant traditionally used for the treatment of malaria in Nigeria are studied alongside two semisynthetic analogues (compounds 4 and 5) of cycleanine. " 01/01/2021 - "The in vivo antimalarial activity of cycleanine is then investigated in suppressive, prophylactic, and curative murine malaria models after infection with a chloroquine-sensitive Plasmodium berghei strain. "
5.	Infections 01/01/2021 - "The in vivo antimalarial activity of cycleanine is then investigated in suppressive, prophylactic, and curative murine malaria models after infection with a chloroquine-sensitive Plasmodium berghei strain. "

Related Drugs and Biologics

1.	Alkaloids
2.	Benzylisoquinolines
3.	Caspases
4.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
5.	Chloroquine (Aralen)
6.	Antimalarials (Antimalarial Agents)
7.	Poly (ADP-Ribose) Polymerase-1
8.	tetrandrine