galangin

01/01/2019 - "In addition, galangin was not exerting any cytotoxicity at the concentrations that were effective against inflammation as assessed by CCK8 assay. "
01/01/2019 - "Therefore, this study aimed at investigating the molecular mechanism of galangin in the attenuation of UA induced renal inflammation in normal rat kidney epithelial cells NRK-52E. "
01/01/2019 - "In conclusion, galangin alleviated DR by attenuating BRB damage via inhibiting microglia-triggered inflammation and further reversing TNFα-induced BRB dysfunction by abrogating oxidative stress injury via activating Nrf2."
12/21/2017 - "Galangin has been shown to inhibit inflammation in a variety of diseases, but not PD. "
10/15/2017 - "Pretreatment with galangin (100mg/kg p.o.) preserved renal function, morphology, suppressed oxidative stress, inflammation and the activation of apoptotic pathways. "

12/01/2021 - "These findings indicated that delivery of galangin by NLC-RGD makes it an effective adjuvant to increase the efficacy of chemotherapeutic agents in cancer treatment."
11/01/2018 - "Galangin (Ga) has been demonstrated to possess anti-cancer effect, but the efficacy of Ga was limited by its low permeability and poor solubility. "
01/01/2022 - "Although further studies are needed for confirming the anti-cancer potential of galangin in vivo malignant systems, exploring this natural compound might open new perspectives in molecular oncology."
07/25/2023 - "Galangin enhances T-cell activity and inhibits tumor cell proliferation, migration, and invasion through PD-L1. "
07/25/2023 - "In vivo experiments showed that galangin suppressed tumor growth. "

12/05/2022 - "Galangin ameliorates osteoarthritis progression by attenuating extracellular matrix degradation in chondrocytes via the activation of PRELP expression."
01/01/2021 - "Galangin attenuates IL-1β-induced catabolism in mouse chondrocytes and ameliorates murine osteoarthritis."
09/05/2021 - "Chondroprotective and antiarthritic effects of galangin in osteoarthritis: An in vitro and in vivo study."
09/25/2023 - "Based on the above bioactivities, more and more attention has been paid to the role of galangin in neurodegenerative diseases, rheumatoid arthritis, osteoarthritis, osteoporosis, skin diseases, and cancer. "
07/01/2023 - "We observed that galangin was well tolerated and positively impacted disease underlying inflammation for the renal, hepatic, central nervous system, cardiovascular, gastrointestinal system, skin, and respiratory disorders, as well as ulcerative colitis, acute pancreatitis, retinopathy, osteoarthritis, osteoporosis, and rheumatoid arthritis. "

11/05/2015 - "In conclusion, Galangin might function as an anti-ischemic stroke drug by improving the microenvironment of NVUs. "
11/09/2012 - "All these data in this study demonstrated that galangin might have therapeutic potential for ischemic stroke and play its protective role through the improvement in rCBF, mitochondrial protection and inhibiting caspase-dependent mitochondrial cell death pathway for the first time."
11/09/2012 - "By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke."
04/06/2016 - "By metabolite-protein network analysis and molecular docking, six of 28 proteins were identified and might become potential galangin biomarkers for acute ischemic stroke. "
04/06/2016 - "We have reported that galangin provides direct protection against ischemic injury as a potential neuroprotective agent and has potential therapeutic effects on the changes of serum amino acids in ischemic stroke; however, the mechanism of the changes of amino acids in the ischemic brain tissue has not yet been clarified. "

01/01/2021 - "Erratum: Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy [Corrigendum]."
01/01/2020 - "Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy."
01/01/2020 - "We examined whether the curcumin derivative galangin could reduce the fatty degeneration of liver tissue in mice with NAFLD by inducing autophagy, from the perspective of both prevention and treatment. "