|1.||Tsugane, Shoichiro: 2 articles (03/2015 - 01/2009)|
|2.||Yoshida, Teruhiko: 2 articles (03/2015 - 01/2009)|
|3.||Sakamoto, Hiromi: 2 articles (03/2015 - 01/2009)|
|4.||Iwasaki, Motoki: 2 articles (03/2015 - 01/2009)|
|5.||Nagao, Minako: 2 articles (07/2003 - 01/2002)|
|6.||Ushijima, Toshikazu: 2 articles (07/2003 - 01/2002)|
|7.||Sugimura, Takashi: 2 articles (07/2003 - 01/2002)|
|8.||Takachi, Ribeka: 1 article (03/2015)|
|9.||Yamaji, Taiki: 1 article (03/2015)|
|10.||Sasazuki, Shizuka: 1 article (03/2015)|
05/25/1998 - "As we previously reported, administration of 300 ppm of MeIQ in a diet for 12 weeks induced lacI mutants at the highest frequency in colonocytes, and at only less than one-tenth of the colon in cells of the liver, forestomach and bone marrow, indicating no direct correlation between the lacI mutant frequency (MF) and cancer incidence (CI). "
05/25/1998 - "No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice."
04/01/1997 - "The mutational characteristics of MeIQ in the lacI gene coincided well with those in the Ha-ras gene of MeIQ-induced mouse forestomach tumors and rat Zymbal gland tumors. "
02/01/1997 - "p53 mutations in MeIQ-induced mouse forestomach tumors."
08/01/1986 - "Carcinogenicity tests on MeIQ are ongoing, and interim data by week 83 show that MeIQ also induces forestomach tumors in addition to liver tumors. "
|2.||Hepatocellular Carcinoma (Hepatoma)
05/25/1998 - "With the administration of 300 ppm of MeIQ in their diet for 92 weeks, the Big Blue female mice developed intestinal tumors and hepatocellular carcinomas. "
11/01/1986 - "The incidences of liver tumors (hepatocellular carcinomas and hepatocellular adenomas) in female mice given 0.04 and 0.01% MeIQ were significantly higher than those in controls. "
07/30/2003 - "In this study, we screened liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in CDF1 mice for beta-catenin and APC mutations and other genetic alterations shown to occur in human hepatocellular carcinomas (HCC), including mutations in the p53 and H-ras genes, c-myc amplification and E-cadherin promoter methylation. "
11/01/1999 - "In order to study the mutagenic effects of heterocyclic aromatic amines (HAAs) in cells of human origin, five compounds, namely 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ), 2-amino-3, 4-dimethyl-imidazo[4,5-f]quinoline (MeIQ), 2-amino-3, 8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx), the pyridoimidazo derivative 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), were tested in micronucleus (MN) assays with a human derived hepatoma (HepG2) cell line. "
|3.||Chromosome Aberrations (Chromosome Abnormalities)
06/01/1998 - "In this paper, we demonstrate the induction of chromosome aberrations in mice chronically exposed to MeIQ in their diet. "
06/01/1998 - "Chromosome aberrations induced in mice by chronic feeding of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ)."
09/01/1992 - "Glu-P-2, IQ, MeIQ, harman, and harmine did not induce chromosome aberrations by themselves at the concentrations used in this study. "
09/01/1992 - "A alpha C, MeA alpha C, Glu-P-1, Glu-P-2, IQ, MeIQ, harman and harmine increased chromosome aberrations only in the presence of S9 mix. "
03/01/2015 - "This study suggests that high MeIQ and total HCA estimates are positively associated with colorectal adenoma risk. "
03/01/2015 - "High intake of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) and total HCA was associated with an increased risk of colorectal adenoma in women but not in men. "
01/01/1985 - "In mice given diet containing 0.04% or 0.01% MeIQ, squamous cell carcinomas and papillomas of the forestomach developed at high incidences. "
01/01/1991 - "In the case of MeIQ, point mutations at the second nucleotide of codon 13 were found in nine of the total 14 Zymbal gland SCCs and in one papilloma. "
11/01/1986 - "The incidences of forestomach tumors (squamous cell carcinomas and papillomas) were also significantly higher in both sexes of mice given MeIQ. "
02/01/1997 - "It was therefore used to analyse the role of p53 gene mutations in forestomach carcinogenesis induced by MeIQ, by examining four original tumors, one papilloma, two primary carcinomas and one lymph node metastasis. "
|2.||2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridine
|1.||Fat-Restricted Diet (Diet, Fat Restricted)