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concanamycin B
from Streptomyces diastatochromogenes S-45; structure given in first source
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Lactones: 1549
Macrolides: 4391
concanamycin B: 3
Polyketides: 231
Macrolides: 4391
concanamycin B: 3
Polycyclic Compounds: 6
Macrocyclic Compounds: 15
Polyketides: 231
Macrolides: 4391
concanamycin B: 3
Experts
1.
Imoto, Masaya
: 1 article (09/2002)
2.
Yoshimoto, Yuya
: 1 article (09/2002)
Related Diseases
1.
Hepatocellular Carcinoma (Hepatoma)
09/05/1993 - "
We have examined the effects of concanamycin B on the constitutive secretory pathway of the human hepatoma cell line, HepG2.
"
2.
Carcinoma (Carcinomatosis)
09/10/2002 - "
In the course of screening for compounds that induce apoptosis in EGFR-overexpressing human epidermal carcinoma A431 cells from secondary metabolites of microorganisms, we found that vacuolar-type H(+)-ATPase (V-ATPase) inhibitors, such as concanamycin B and destruxin E, induced apoptosis only when the cells were stimulated with EGF.
"
3.
Bone Resorption
02/01/1996 - "
Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro.
"
02/01/1996 - "
Effects of concanamycin B, a specific inhibitor of the vacuolar type H(+)-ATPase (V-ATPase), on the stimulation of bone resorption induced by parathyroid hormone (PTH) were examined in vitro.
"
Related Drugs and Biologics
1.
Proton-Translocating ATPases (ATPase, H+)
2.
Adenosine Triphosphatases (ATPase)
3.
Vacuolar Proton-Translocating ATPases (V-Type ATPase)
4.
Parathyroid Hormone (Parathormone)
5.
Epidermal Growth Factor (EGF)
6.
destruxin E