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M 92 (VA 2)

from Micromonospora verruculosa; may consist of juglone conjugated with naphthazarin

Also Known As:

VA 2; M-92; VA-2; Antibiotic M 92

Networked: 28 relevant articles (5 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Naphthoquinones: 418
        M 92: 28
- Quinones: 434
  - Naphthoquinones: 418
    - M 92: 28
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Naphthoquinones: 418
      - M 92: 28

Experts

1.	Barth, Sebastian: 1 article (12/2021)
2.	Foldyna, Borek: 1 article (12/2021)
3.	Halbfass, Philipp: 1 article (12/2021)
4.	Hautmann, Martina B: 1 article (12/2021)
5.	Kerber, Sebastian: 1 article (12/2021)
6.	Kikec, Jan: 1 article (12/2021)
7.	Lehmkuhl, Lukas: 1 article (12/2021)
8.	Lüsebrink, Ulrich: 1 article (12/2021)
9.	Reents, Wilko: 1 article (12/2021)
10.	Shalla, Alaa: 1 article (12/2021)

Related Diseases

1.	Hypothyroidism 05/01/2007 - "Repletion studies in VA- and iodine-deficient animals suggest: 1) primary hypothyroidism in animals with concurrent moderate VAD and ID does not reduce the efficacy of high doses of oral VA; 2) VAD does not reduce the efficacy of dietary iodine to correct pituitary-thyroid axis dysfunction due to iodine deficiency; and 3) given alone, without iodine repletion, high-dose VA supplementation in combined VAD and ID may reduce thyroid hyperstimulation and reduce risk for goiter."
2.	Goiter 05/01/2007 - "Repletion studies in VA- and iodine-deficient animals suggest: 1) primary hypothyroidism in animals with concurrent moderate VAD and ID does not reduce the efficacy of high doses of oral VA; 2) VAD does not reduce the efficacy of dietary iodine to correct pituitary-thyroid axis dysfunction due to iodine deficiency; and 3) given alone, without iodine repletion, high-dose VA supplementation in combined VAD and ID may reduce thyroid hyperstimulation and reduce risk for goiter."
3.	Tics (Tic) 10/01/2006 - "A majority of patients had improved scores on the TICS (DC to 3 M: 91%; 3 M to 12 M: 82%), BI (DC to 3 M: 96%; 3 M to 12 M: 92%), and SIP (3 M to 12 M: 80%) following aSAH. "
4.	Retinal Detachment (Retinal Detachments) 01/01/2017 - "At the final visit, 5 eyes (50%) had improved VA, 2 eyes (20%) showed stabilisation, and 3 eyes (30%) with total retinal detachment had a decrease in VA. "
5.	Prostatic Neoplasms (Prostate Cancer) 05/01/2015 - "Morphological analysis of VA-2 showed significant reduction of cell number, while the cells' sizes were also markedly increased and were obvious at 68 h of treatment with 1 μM in HCT-116 (colon) and PC-3 (prostate) cancer cells. " 05/01/2015 - "Based on our results, VA-2 was about 9- to 11-times more potent in colon cancer cells and 2- to 3-times more potent in prostate cancer cells compared to HEK293/pcDNA3.1 cells. "

Related Drugs and Biologics

1.	Iodine
2.	fluridil
3.	Valproic Acid (Depakote)
4.	Ovalbumin
5.	Immunoglobulin E (IgE)
6.	Flavonoids
7.	p-Methoxy-N-methylphenethylamine
8.	Monoclonal Antibodies
9.	Acids
10.	hispolon

Related Therapies and Procedures

1.	Penetrating Keratoplasty
2.	Oral Administration