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tyrosyl-prolyl-leucyl-glycinamide
found in rat brain
Also Known As:
N-Tyr-MIF-1; Tyr-MIF-1; Tyr-Pro-Leu-Gly-NH2
Networked:
12
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Peptide Hormones: 1347
Hypothalamic Hormones: 68
Pituitary Hormone Release Inhibiting Hormones
MSH Release-Inhibiting Hormone: 54
tyrosyl-prolyl-leucyl-glycinamide: 12
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Hypothalamic Hormones: 68
Pituitary Hormone Release Inhibiting Hormones
MSH Release-Inhibiting Hormone: 54
tyrosyl-prolyl-leucyl-glycinamide: 12
Peptides: 82426
Neuropeptides: 6772
Hypothalamic Hormones: 68
Pituitary Hormone Release Inhibiting Hormones
MSH Release-Inhibiting Hormone: 54
tyrosyl-prolyl-leucyl-glycinamide: 12
Peptide Hormones: 1347
Hypothalamic Hormones: 68
Pituitary Hormone Release Inhibiting Hormones
MSH Release-Inhibiting Hormone: 54
tyrosyl-prolyl-leucyl-glycinamide: 12
Experts
1.
Bocheva, A
: 1 article (11/2004)
2.
Dzambazova-Maximova, E
: 1 article (11/2004)
Related Diseases
1.
Hyperphagia (Overeating)
01/01/1994 - "
Therefore, the aim of this study was to examine the effects of Tyr-MIF-1 and MIF-1 as opiate antagonists on a naloxone-sensitive PYY model of hyperphagia.
"
01/01/1994 - "
Differential effects of Tyr-MIF-1, MIF-1, and naloxone on peptide YY-induced hyperphagia.
"
2.
Body Weight (Weight, Body)
01/01/1985 - "
Prenatal BE and CRF reduced body weight on day 1, in contrast to Tyr-MIF-1 which produced a significant increase over controls by day 7 as well as a slight but significant acceleration of eye opening.
"
12/01/1999 - "
Effects of neonatal treatment with Tyr-MIF-1 and naloxone on the long-term body weight gain induced by repeated postnatal stressful stimuli.
"
10/15/1993 - "
Animals given morphine alone or in combination with Tyr-MIF-1 had significantly lower body weights for the first 3 weeks of life and delayed eye opening on day 16.
"
12/01/1999 - "
The aim of the present work was to compare the effect of repeated neonatal injections of Tyr-MIF-1 or naloxone on the long-term body weight gain induced by a stressing procedure applied daily during the first three weeks of life.
"
3.
Catalepsy
01/01/1993 - "
Tolerance to SCH 23390-induced catalepsy did not develop during the 11-day treatment, and Tyr-MIF-1 had no effect on SCH 23390-induced catalepsy.
"
01/01/1993 - "
However, tolerance developed to spiperone-induced catalepsy, and Tyr-MIF-1 attenuated this development of tolerance (p < 0.001).
"
01/01/1993 - "
Tyr-MIF-1 attenuates development of tolerance to spiperone-induced catalepsy in rats.
"
06/01/1986 - "
Catalepsy was inhibited in an inverted U-shape dose-response relationship with the maximal effect of each peptide occurring at 1.0 mg/kg. The results indicate that when careful attention is given to dose, both MIF-1 and Tyr-MIF-1 can activate dopaminergic neuronal activity after acute administration.
"
06/01/1986 - "
Acute administration of MIF-1 or Tyr-MIF-1 inhibits haloperidol-induced catalepsy in rats.
"
4.
Acute Pain
11/01/2004 - "
We examined the effects of the Tyr-MIF-1 peptides (all in dose 1 mg/kg i.p.) in the male Wistar rats on morphine-induced analgesia in acute pain using the paw-pressure (PP) and the tail-flick (TF) tests and on immobilization stress-induced antinociception using the PP test.
"
5.
Shock
04/01/1987 - "
In this report experiments are described in which mice were tested on the hot-plate in three models of antinociception - shock, novel environment, and warm-water swim - after the administration of various doses of Tyr-MIF-1 without any exogenous opiates.
"
Related Drugs and Biologics
1.
MSH Release-Inhibiting Hormone (MIF-I)
2.
Opiate Alkaloids
3.
Naloxone (Narcan)
4.
Morphine (MS Contin)
5.
Peptides (Polypeptides)
6.
Peptide YY
7.
Antipsychotic Agents (Antipsychotics)
8.
Spiperone
9.
Picrotoxin
10.
Haloperidol (Haldol)
Related Therapies and Procedures
1.
Injections
2.
Analgesia