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acifran

structure given in first source

Also Known As:

2-methyl-2-phenyl-3(2H)furanone-5-carboxylic acid; AY 25712; AY-25,712; AY-25712; 2-Furancarboxylic acid, 4,5-dihydro-5-methyl-4-oxo-5-phenyl-

Networked: 4 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - acifran: 4

Related Diseases

1.	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/01/1987 - "In this 12-week study acifran provided safe and effective treatment for Type IIa hyperlipoproteinemia." 09/01/1985 - "The hypolipidemic effects of acifran were evaluated in a randomized, double-blind, placebo-controlled study of 30 patients with type IIa hyperlipoproteinemia. " 09/01/1985 - "Controlled trial of acifran in type II hyperlipoproteinemia."
2.	Renal Insufficiency (Renal Failure) 01/01/1990 - "Renal failure substantially reduced the plasma and renal clearance of total and particularly of unbound acifran, moderately reduced its volume of distribution, and increased its elimination half-life from 1.4 to 1.7 hours to 5.7 hours. " 01/01/1990 - "Pharmacokinetics and disposition of the lipid-lowering drug acifran in normal subjects and in patients with renal failure."
3.	Atherosclerosis 07/28/2022 - "Acifran is primarily used in the treatment of dyslipidemia, myocardial infractions, and atherosclerosis in humans due to its lower vascular and metabolic side effects. "
4.	Dyslipidemias (Dyslipidemia) 07/28/2022 - "Acifran is primarily used in the treatment of dyslipidemia, myocardial infractions, and atherosclerosis in humans due to its lower vascular and metabolic side effects. "
5.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/1990 - "In patients with moderate chronic renal failure, the binding of acifran to plasma proteins was decreased, and the plasma concentrations of total and unbound drug were greater than those of healthy subjects. "

Related Drugs and Biologics

1.	Lipids
2.	Blood Proteins (Serum Proteins)