|1.||Hong, Jin Tae: 7 articles (07/2012 - 03/2008)|
|2.||Oh, Ki-Wan: 6 articles (07/2012 - 10/2007)|
|3.||Kwon, Byoung-Mog: 5 articles (01/2014 - 09/2008)|
|4.||Han, Sang Bae: 5 articles (07/2012 - 10/2009)|
|5.||Yun, Yeo-Pyo: 4 articles (12/2012 - 12/2009)|
|6.||Choi, Im Seop: 4 articles (07/2012 - 12/2010)|
|7.||Jung, Jae Kyung: 4 articles (03/2012 - 03/2008)|
|8.||Lee, Seung-Ho: 4 articles (03/2012 - 10/2007)|
|9.||Lee, Jung-Jin: 3 articles (12/2012 - 12/2009)|
|10.||Choi, Dong-Young: 3 articles (07/2012 - 01/2012)|
|1.||Carotid Artery Injuries
01/01/2011 - "The purpose of this study was to determine the effects of obovatol on thrombus formation in vivo and platelet activation in vitro and ex vivo. "
01/01/2011 - "We investigated the antiplatelet and antithrombotic activities of obovatol in rat carotid arterial thrombosis in vivo along with platelet aggregation in vitro and ex vivo. "
01/01/2011 - "Antiplatelet activity of obovatol, a biphenolic component of Magnolia Obovata, in rat arterial thrombosis and rabbit platelet aggregation."
12/15/2010 - "Previously, we found that obovatol, a lignan compound isolated from Magnolia officinalis, has anti-cancer, anti-inflammatory, and anxiolytic effects. "
09/15/2008 - "In nude mice bearing SW620-incubated tumor, obovatol exhibited more potent antitumor activity than honolkiol. "
09/15/2008 - "Obovatol inhibited tumor growth that accounted for 50% decrease in tumor volume and 44.6% decrease in tumor weight at the end of the experiment without any adverse health effect. "
09/15/2008 - "Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis."
10/01/2009 - "The combination treatment with each drug at one half the respective IC(50) dose (5 microM obovatol + 5 nM docetaxel) was more effective and significant (60%-70%) in the inhibition of cancer cell growth than single treatment by each drug (20%-40%); inhibition was exerted through a significant increase of apoptosis induction (60%-80%) by the combination treatment compared to the single treatment (10%-30%). "
|4.||Stomach Ulcer (Gastric Ulcer)
12/01/2012 - "Obovatol has been reported biological activities such as muscle relaxative, anti-gastric ulcer, anti-allergic and anti-bacterial activities. "
12/10/2009 - "Obovatol is known to have various biological activities such as muscle relaxation, anti-gastric ulcer, anti-inflammatory, anti-allergic, and anti-bacterial activities. "
|5.||Colonic Neoplasms (Colon Cancer)
03/17/2008 - "These results suggest that obovatol inhibits prostate and colon cancer cell growth via induction of apoptotic cell death, and that inhibition of NF-kappaB may be a significant as its action mechanism."
03/17/2008 - "Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB."
03/17/2008 - "We investigated here whether obovatol could inhibit NF-kappaB activity, and thereby inhibit cancer cell growth in prostate (LNCaP and PC-3) and colon cancer (SW620 and HCT116) cells. "
10/01/2009 - "Obovatol enhances docetaxel-induced prostate and colon cancer cell death through inactivation of nuclear transcription factor-kappaB."
10/01/2009 - "We investigated here whether obovatol could sensitize cancer cells against docetaxel through inhibition of NF-kappaB activity in prostate cancer (LNCaP and PC-3) and colon cancer (SW620 and HCT116) cells. "
|2.||NF-kappa B (NF-kB)
|5.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|6.||Transcription Factors (Transcription Factor)