HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

obovatol

antineoplastic agent from Magnolis obovata; structure given in first source

Also Known As:

4',5-diallyl-2,3-dihydroxybiphenyl ether

Networked: 22 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phenyl Ethers: 8
        obovatol: 22
        Biphenyl Compounds: 7
        obovatol: 22
- Ethers: 242
  - Phenyl Ethers: 8
    - obovatol: 22

Experts

1.	Kwon, Byoung-Mog: 7 articles (11/2017 - 09/2008)
2.	Hong, Jin Tae: 7 articles (07/2012 - 03/2008)
3.	Oh, Ki-Wan: 6 articles (07/2012 - 10/2007)
4.	Han, Sang Bae: 5 articles (07/2012 - 10/2009)
5.	Yun, Yeo-Pyo: 4 articles (12/2012 - 12/2009)
6.	Choi, Im Seop: 4 articles (07/2012 - 12/2010)
7.	Jung, Jae Kyung: 4 articles (03/2012 - 03/2008)
8.	Lee, Seung-Ho: 4 articles (03/2012 - 10/2007)
9.	Lee, Jung-Jin: 3 articles (12/2012 - 12/2009)
10.	Choi, Dong-Young: 3 articles (07/2012 - 01/2012)

Related Diseases

1.	Neuroinflammatory Diseases 01/01/2012 - "The anti-neuroinflammation and anti-amyloidogenesis by obovatol were replicated in in vitro studies. " 03/01/2012 - "In conclusion, our data demonstrated that obovatol prevented memory impairments in experimental AD models, which could be attributable to amelioration of neuroinflammation and amyloidogenesis by inhibition of NF-κB signaling pathway and anti-fibrillogenic activity of obovatol." 01/01/2012 - "These results show that obovatol mitigates LPS-induced amyloidogenesis and memory impairment via inhibiting NF-κB signal pathway, suggesting that the compound might be plausible therapeutic intervention for neuroinflammation-related diseases such as AD." 04/01/2010 - "Obovatol is not only a useful chemical tool that can be used to investigate microglial signalling, but also a promising drug candidate against neuroinflammatory diseases. " 04/01/2010 - "In addition, obovatol protected cultured neurons from microglial toxicity and inhibited neuroinflammation in mice in vivo. "
2.	Carotid Artery Injuries 06/01/2010 - "In the present study, we investigated the inhibitory effects of obovatol on in vitro vascular smooth muscle cell (VSMC) proliferation and in vivo neointimal formation in a rat carotid artery injury model. "
3.	Thrombosis (Thrombus) 01/01/2011 - "The purpose of this study was to determine the effects of obovatol on thrombus formation in vivo and platelet activation in vitro and ex vivo. " 01/01/2011 - "We investigated the antiplatelet and antithrombotic activities of obovatol in rat carotid arterial thrombosis in vivo along with platelet aggregation in vitro and ex vivo. " 01/01/2011 - "Antiplatelet activity of obovatol, a biphenolic component of Magnolia Obovata, in rat arterial thrombosis and rabbit platelet aggregation."
4.	Leiomyoma (Uterine Fibroids) 01/01/2020 - "The present study was aimed to examine the inhibitory and protective (anti-proliferative and apoptotic) effect of the obovatol (OB) in human leiomyoma cells (HuLM). " 01/01/2020 - "Inhibitory and protective effect of obovatol against uterine fibroid (leiomyoma) cells."
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/01/2016 - "Thus, in the present study, the antitumour molecular mechanism of obovatol was investigated in non-small cell lung cancer cells (NSCLCs). " 11/01/2016 - "Obovatol Induces Apoptosis in Non-small Cell Lung Cancer Cells via C/EBP Homologous Protein Activation."

Related Drugs and Biologics

1.	honokiol
2.	magnolol
3.	Anti-Allergic Agents (Antiallergic Agents)
4.	Lignans
5.	NF-kappa B (NF-kB)
6.	Transcription Factor CHOP
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Transcription Factors (Transcription Factor)
9.	Anti-Anxiety Agents (Anxiolytics)
10.	Scopolamine (Hyoscine)

Related Therapies and Procedures

1.	Oral Administration