iodothiouracil

07/01/1986 - "Iodothiouracil as a melanoma localizing agent."
01/01/1992 - "Previous studies on mice carrying melanoma have shown that 5-iodo-2-thiouracil (ITU) is accumulated in the tumours due to its specific incorporation into melanin during its synthesis. "
06/01/1991 - "To be clinically useful in melanoma scanning, thiouracil has been radioiodinated, and 5-iodo-2-thiouracil (ITU) was found to be localized in melanotic melanoma as selectively as thiouracil. "
01/01/1989 - "5-Iodo-2-thiouracil (ITU) is of interest due to its ability to bind specifically to the pigment melanin during melanogenesis and is of potential value in the diagnosis and treatment of malignant melanoma. "
07/01/1986 - "The variety of iodine isotopes available makes iodothiouracil a particularly promising melanoma-localizing agent. "

09/01/1951 - "Therapeutic studies in hyperthyroidism: sodium 5-iodo-2-thiouracil."

03/03/1955 - "[Potassium perchlorate and iodothiouracil in thyrotoxicosis]."

07/01/1986 - "Tumor uptake and biodistribution of [35S]thiouracil and iodothiouracil (both iodine-127 (127I) and iodine-125 (125I) labeled) have been compared and were found to be essentially the same. "

07/01/1986 - "Iodothiouracil was also shown to localize in remote secondary metastases using a metastatic variant of the Harding-Passey melanoma currently being developed in our laboratory. "