|1.||Tizabi, Yousef: 6 articles (01/2014 - 11/2005)|
|2.||McBride, William J: 4 articles (02/2010 - 03/2003)|
|3.||Antkiewicz-Michaluk, L: 4 articles (10/2008 - 01/2000)|
|4.||Ebadi, Manuchair: 4 articles (03/2007 - 11/2003)|
|5.||Deng, Yulin: 3 articles (05/2015 - 03/2013)|
|6.||Antkiewicz-Michaluk, Lucyna: 3 articles (05/2015 - 01/2003)|
|7.||Kang, Jung Hoon: 3 articles (02/2013 - 07/2009)|
|8.||Taylor, Robert E: 3 articles (10/2011 - 11/2005)|
|9.||Li, Ting-Kai: 3 articles (02/2010 - 03/2003)|
|10.||Bell, Richard L: 3 articles (03/2008 - 03/2003)|
07/12/2006 - "In this study, we sought to determine whether salsolinol-induced cytotoxicity in SH-SY5Y human neuroblastoma cells, a cloned cell line which expresses dopaminergic activity, could be prevented by overexpressing a Ca(2+) channel, transient receptor potential (TRPC1) protein. "
07/12/2006 - "Interestingly, overexpression of TRPC1 increases TRPC1 protein levels and also protected SH-SY5Y neuroblastoma cells against salsolinol-mediated cytotoxicity as determined by 3,[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. "
02/07/2000 - "Thus, we correlated indices of cellular energy production and cell viability in human dopaminergic neuroblastoma SH-SY5Y cells after exposure to salsolinol and compared these results with data obtained with MPP(+). "
02/07/2000 - "1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism."
05/01/2015 - "Salsolinol Damaged Neuroblastoma SH-SY5Y Cells Induce Proliferation of Human Monocyte THP-1 Cells Through the mTOR Pathway in a Co-culture System."
|2.||Parkinson Disease (Parkinson's Disease)
02/01/2013 - "Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol), an endogenous neurotoxin, is known to perform a role in the pathogenesis of Parkinson's disease (PD). "
01/01/2011 - "Increased salsolinol levels are detected in the cerebrospinal fluid of Parkinson's disease patients. "
05/01/2010 - "1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol), an endogenous neurotoxin present in the mammalian brain, is known to perform a role in the pathogenesis of Parkinson's disease. "
03/01/2007 - "Salsolinol, an endogenous neurotoxin, is known to be involved in the pathogenesis of Parkinson's disease (PD). "
07/12/2006 - "Salsolinol, an endogenous neurotoxin, may be involved in the pathogenesis of Parkinson's disease. "
|3.||Alcoholism (Alcohol Abuse)
10/01/2002 - "The findings of this study support the theory that salsolinol might be a trait marker in alcoholism."
03/01/2008 - "Quantitative chiral analysis of salsolinol in different brain regions of rats genetically predisposed to alcoholism."
10/01/2002 - "Endogenous 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) could be a potential marker involved in the aetiology of alcoholism. "
12/10/1999 - "Endogenous 1-methyl-1, 2, 3, 4-tetrahydro-6,7-dihydroxyisoquinoline (salsolinol) could be a potential marker involved in the etiology of alcoholism. "
04/01/1999 - "To explore the hypothesis that endogenous 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) might be involved in the etiology of alcoholism, its concentration was determined in the striatum and adrenal gland of rats bred selectively for disparate alcohol drinking. "
|4.||Parkinsonian Disorders (Parkinsonism)
11/01/2003 - "Salsolinol causing parkinsonism activates endoplasmic reticulum-stress signaling pathways in human dopaminergic SK-N-SH cells."
04/01/1992 - "(+-)-Salsolinol , a substance possibly inducing parkinsonism, was biotransformed into optically active O- and/or N-methylated salsolinols 5, 6, and 7 by several Papaveraceae plants and tissue-culture cells derived from these plants. "
09/01/1997 - "The results suggest that salsolinol in the cerebrospinal fluid does not originate from exogenous l-dopa and its elevation in cerebrospinal fluid may be an indicator of the advancement of parkinsonism."
09/01/1997 - "The analysis of the results demonstrated that the concentration of salsolinol was related to the degree of parkinsonism but not affected by l-dopa treatment. "
07/01/2006 - "1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), an endogenous parkinsonism-preventing substance, and its 5-, 6-, and 7-hydroxylated derivatives are reported to show in vitro neuroprotective activity against toxicity due to salsolinol in SH-SY5Y human neuroblastoma cells. "
|5.||Neurodegenerative Diseases (Neurodegenerative Disease)
07/10/2009 - "Salsolinol is an endogenous neurotoxin, known to be involved in the pathogenesis of neurodegenerative disorders. "
06/01/2012 - "The purpose of this study was to investigate the effects of glutathione on 3-hydroxykynurenine, 6-hydroxydopamine and salsolinol mediated neurotoxicity in the human neuroblastoma SH-SY5Y cell line in order to find a possible therapeutic application of this compound to neurodegenerative disorders. "
|2.||Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
|5.||Amyloid (Amyloid Fibrils)
|9.||Levodopa (L Dopa)
|10.||JNK Mitogen-Activated Protein Kinases
|1.||Transplantation (Transplant Recipients)