|1.||Wang, Zhong-Feng: 4 articles (12/2005 - 12/2003)|
|2.||Shi, Yu-Liang: 4 articles (12/2005 - 12/2003)|
|3.||Tang, Mian-Zhi: 3 articles (12/2005 - 12/2003)|
|4.||Shi, Yu-liang: 2 articles (01/2006 - 05/2004)|
|5.||Feng, Cheng-Cheng: 1 article (11/2015)|
|6.||Lu, Yun-Min: 1 article (11/2015)|
|7.||Chu, Shao-Jun: 1 article (11/2015)|
|8.||Zhu, Jin-Shui: 1 article (11/2015)|
|9.||Zhang, Jing: 1 article (11/2015)|
|10.||Zhang, Rui: 1 article (11/2015)|
11/01/2011 - "Toosendanin, a triterpenoid from Melia toosendan Sieb et Zucc, has been found before to be an effective anti-botulism agent, with a bi-phasic effect at both motor nerve endings and central synapse: an initial facilitation followed by prolonged depression. "
09/15/2011 - "Toosendanin, a drug with therapeutic effects against botulism, inhibited GT1b-dependent BoNT/B oligomerization and in parallel truncated BoNT/B single-channel conductance, suggesting that oligomerization plays a role in the translocation reaction. "
06/01/2004 - "In spite of sharing some similar action with BoNT, toosendanin can protect botulism animals that have been administrated with lethal doses of BoNT/A or BoNT/B for several hours from death and make them restore normal activity. "
06/01/2004 - "Cure of experimental botulism and antibotulismic effect of toosendanin."
03/01/1985 - "The effect of toosendanin on monkey botulism."
09/01/2010 - "In this study we used both in vivo and in vitro models to investigate the anti-cancer effects of toosendanin and their possible molecular mechanisms. "
12/01/2005 - "In the present study, we investigated the growth inhibition and apoptosis-induced effect of toosendanin on human cancer cells. "
11/01/2015 - "Toosendanin (TSN) is a triterpenoid extracted from the bark or fruits of Melia toosendan Sieb et Zucc and possesses antitumour effects on various human cancer cells. "
01/01/2012 - "Triterpenoid toosendanin (TSN) exhibits potent cytotoxic activity through inducing apoptosis in a variety of cancer cell lines. "
12/01/2005 - "The result showed that toosendanin significantly suppressed the proliferation of tested human cancer cell lines. "
|4.||Colorectal Neoplasms (Colorectal Cancer)
|5.||Hepatocellular Carcinoma (Hepatoma)
09/01/2010 - "The findings above demonstrate that toosendanin possesses strong anticancer effects in vivo and in vitro via inducing mitochondria-dependent apoptosis in hepatocellular carcinoma cells."
09/01/2010 - "In the in vitro experiment, human hepatocellular carcinoma cell lines [SMMC-7721(p53+) and Hep3B (p53-)] were coincubated with toosendanin of different concentrations (0.1~ 0.9 µM). "
09/01/2010 - "Toosendanin inhibits hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis."
09/01/2010 - "Results from morphological analysis, annexin V staining, detection of caspases activity, and expressions of Bcl-2, Bax, and Fas indicated that the anticancer effects of toosendanin were associated with its induction of apoptosis via the mitochondria-dependent pathway in p53- and p53+ hepatocellular carcinoma cells. "
|1.||Chinese Traditional Medicine (Traditional Chinese Medicine)