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pre-prodynorphin

characterized; contains 256 amino acid residues; opioid peptide
Also Known As:
preprodynorphin
Networked: 30 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Lao, Lixing: 4 articles (10/2008 - 12/2003)
2. Qiao, Jian-Tian: 4 articles (10/2008 - 12/2003)
3. Zhang, Rui-Xin: 4 articles (10/2008 - 12/2003)
4. Abraham, K E: 3 articles (07/2001 - 01/2000)
5. Brewer, K L: 3 articles (07/2001 - 01/2000)
6. Labombarda, Florencia: 2 articles (01/2011 - 12/2008)
7. Liu, Bing: 2 articles (10/2008 - 03/2005)
8. Ruda, Mary Ann: 2 articles (04/2004 - 12/2003)
9. Imbe, H: 2 articles (01/2001 - 03/2000)
10. McGinty, J F: 2 articles (01/2001 - 01/2000)

Related Diseases

1. Inflammation
2. Pain (Aches)
12/26/2003 - "Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammation."
03/01/1990 - "3. Further, we discuss the regulation of expression of two opioid peptides, preproenkephalin and preprodynorphin, in laminae I and II of the spinal cord and in nucleus caudalis of the trigeminal nuclear complex, where they may play a role in pain modulation. "
09/01/1999 - "TMJ inflammation resulted in more robust changes in MDH nociceptive neurons as compared with PO inflammation, consistent with previous studies of increased inflammation, increased MDH Fos-protein expression, and increased MDH preprodynorphin mRNA expression in this deep tissue orofacial model of pain and hyperalgesia. "
07/20/2001 - "The opioids are classically involved in the suppression of pain transmission but specifically, dynorphin, has been implicated in the secondary pathophysiologic response to SCI. Activation of the immediate early gene, c-fos, has been implicated in the induction of preprodynorphin (PPD) gene expression and therefore, may be an important intermediate step in the generation of the opioid response to SCI. The purpose of this study was to investigate whether intraspinal QUIS injection induces c-fos expression within the spinal cord. "
07/01/2015 - "Even though the rewarding effects induced by (±)-pentazocine were significantly suppressed under pain induced by formalin, accompanied by increase of preprodynorphin mRNA levels in the nucleus accumbens, a high dose of (±)-pentazocine produced significant rewarding effects under pain. "
3. Hyperalgesia
4. Spinal Cord Injuries (Spinal Cord Injury)
5. Seizures (Seizure)

Related Drugs and Biologics

1. Messenger RNA (mRNA)
2. Tuberculin (PPD)
3. Freund's Adjuvant
4. preproenkephalin
5. Dynorphins (Dynorphin)
6. Opioid Peptides (Opioid Peptide)
7. Dexamethasone (Maxidex)
8. Opioid Analgesics (Opioids)
9. N-Methylaspartate (NMDA)
10. Formaldehyde (Formol)

Related Therapies and Procedures

1. Adrenalectomy
2. Electroacupuncture
3. Spinal Injections