TAC 278

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4 relevant articles (0 outcomes, 0 trials/studies) found for this Bio-Agent

Description: prodrug of 5-fluorouracil; RN given refers to cpd with unspecified isomeric designation

Also Known As:

5-Pyrimidinecarboxylic acid, 4-butoxy-5-fluorohexahydro-2,6-dioxo-, ethyl ester, cis-(+-)-; TAC 278, (cis-(+-))-isomer; TAC-278; ethyl t-butoxy-5-fluoro-hexahydro-2,4-dioxopyrimidine-5-carboxylate; 5-Pyrimidinecarboxylic acid, 4-butoxy-5-fluorohexahydro-2,6-dioxo-, ethyl ester

Bio-Agent Context: Research Results

Heterocyclic Compounds: 25

1-Ring Heterocyclic Compounds

Related Diseases

1.	Neoplasms (Cancer) 03/01/1982 - "A new fluorinated pyrimidine, TAC-278, was studied for its safety, anti-tumor activity and pharmacokinetics in patients with solid tumors of various types. " 03/01/1982 - "Concentration of 5-FU in body fluid and tumor tissues were high following oral administration of TAC-278, but the disappearance was relatively rapid. " 08/01/1982 - "In this paper, UFT, TAC-278, and 5'-DFUR, were particularly investigated from the point of view of pharmacokinetics of those drugs (or 5-FU) in the blood, normal and tumor tissues of patients with gastric cancer. " 01/01/1982 - "On the contrary, 133 mg/m2 of TAC-278, and 200 mg/m2 or 300 mg/m2 of 5'-DFUR (which is activated by thymidine phosphorylase in man) did not produce an effective 5-FU concentration in tumor tissues. " Order ALL the reference details at left...
2.	Stomach Neoplasms (Stomach Cancer) 08/01/1982 - "In this paper, UFT, TAC-278, and 5'-DFUR, were particularly investigated from the point of view of pharmacokinetics of those drugs (or 5-FU) in the blood, normal and tumor tissues of patients with gastric cancer. " Order ALL the reference details at left...
3.	Hydrocephalus (Hydrocephaly) 03/01/1983 - "Seven patients had had irradiation and also had V-P shunt operation for hydrocephalus 5-FU concentration in CSF was extremely high in FD-1 and TAC-278 administration, but not in Tegafur and HCFU administration. " Order ALL the reference details at left...
4.	Brain Neoplasms (Brain Tumor) 03/01/1983 - "Transfer of systemically administered fluorinated pyrimidines (Tegafur, TAC-278, HCFU and FD-1) to cerebrospinal fluid was studied in 7 patients primary brain tumors. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	doxifluridine
3.	Thymidine Phosphorylase
4.	Pyrimidines
5.	Tegafur
6.	pyrimidine
7.	1-hexylcarbamoyl-5-fluorouracil (carmofur)
8.	FD 1

Related Therapies and Procedures

1.	Oral Administration

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