1-amino-1,3-dicarboxycyclopentane

RN given refers to (cis)-isomer

Also Known As:

(trans)-1-aminocyclopentyl-1,3-dicarboxylate; 1-amino-1,3-dicarboxycyclopentane, (cis)-(+-)-isomer; 1-amino-1,3-dicarboxycyclopentane, (trans)-(+-)-isomer; 1-amino-1,3-dicarboxycyclopentane, (trans)-isomer; 1-amino-1,3-dicarboxycyclopentane, cis-(1R,3R)-isomer; 1-amino-1,3-dicarboxycyclopentane, cis-(1S,3S)-isomer; 1-amino-1,3-dicarboxycyclopentane, trans-(1R,3S)-isomer; 1-amino-cyclopentyl-trans-1S,3R-dicarboxylate; 1-aminocyclopentane-1,3-dicarboxylic acid; 1-aminocyclopentyl-1,3-dicarboxylic acid; 1R,3S-ACPD; 1S,3R-ACPD; ACPD-1S,3R; cis-1-amino-1,3-cyclopentanecarboxylic acid; cis-ACPD; t-ACPD; trans-1-aminocyclopentane-1,3-dicarboxylate; trans-ACPD

Networked: 29 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Santos, Adair R S: 3 articles (08/2014 - 04/2009)
2.	Martins, Daniel F: 2 articles (08/2014 - 02/2013)
3.	Antunes, Vagner R: 2 articles (06/2006 - 05/2004)
4.	Machado, Benedito H: 2 articles (06/2006 - 05/2004)
5.	Chen, X: 1 article (03/2016)
6.	Liu, J: 1 article (03/2016)
7.	Liu, Y: 1 article (03/2016)
8.	Lu, H: 1 article (03/2016)
9.	Miao, X: 1 article (03/2016)
10.	Tian, Y: 1 article (03/2016)

Related Diseases

1.	Brain Injuries (Brain Injury) 10/01/1993 - "1S,3R-ACPD brain injury occurred in the absence of prominent behavioral convulsions. " 05/14/1992 - "Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed by hemispheric weight disparities. " 10/01/1993 - "Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist." 10/08/1993 - "Furthermore, AOAA potentiated NMDA, but not AMPA or 1S,3R-ACPD, induced brain injury. " 10/01/1993 - "As indexed by hemispheric brain weight differences 5 d postinjection, unilateral intrastriatal injection of 1S,3R-ACPD (0.1-2.0 mumol/microliters), but not 1R,3S-ACPD, produced dose-dependent brain injury (maximal effect of 3.4 +/- 0.5% damage). "
2.	Hypoxia (Hypoxemia) 03/31/2016 - "Activation of mGluRs by glutamate or Trans-ACPD (a non subtype-selective mGluRs agonist) sensitized NSCs to the growth effects of hypoxia. " 02/22/2002 - "NAAG, L-AP4 and t-ACPD all significantly decreased hypoxia-ischemia-induced elevation of cAMP. " 12/14/1998 - "The formation of lamellar bodies by t-ACPD or by anoxia was blocked by pretreatment of L(+)-2-amino-3-phosphonopropionic acid (L-AP3), which is an antagonist for the metabotropic glutamate receptor. " 02/22/2002 - "LY341495 blocked the effect of NAAG, but not of L-AP4 or t-ACPD, on hypoxia-ischemia-stimulated cAMP elevation. " 02/22/2002 - "While L(+)-2-Amino-4-phosphonobutyric acid (L-AP4) and trans-[1S,3R]-1-Amino-cyclopentane-1, 3-dicarboxylic acid (t-ACPD) were unable to provide protection against hypoxic-ischemic brain injury, 2-(phosphonomethyl) pentanedioic acid (2-PMPA), an inhibitor of N-acetylated alpha-linked acidic dipeptidase (NAALADase), which hydrolyzes endogenous NAAG into N-acetyl-aspartate and glutamate, significantly reduced neonatal hypoxia-ischemia-induced brain injury. "
3.	Ischemia 02/22/2002 - "NAAG, L-AP4 and t-ACPD all significantly decreased hypoxia-ischemia-induced elevation of cAMP. " 02/22/2002 - "LY341495 blocked the effect of NAAG, but not of L-AP4 or t-ACPD, on hypoxia-ischemia-stimulated cAMP elevation. " 02/22/2002 - "While L(+)-2-Amino-4-phosphonobutyric acid (L-AP4) and trans-[1S,3R]-1-Amino-cyclopentane-1, 3-dicarboxylic acid (t-ACPD) were unable to provide protection against hypoxic-ischemic brain injury, 2-(phosphonomethyl) pentanedioic acid (2-PMPA), an inhibitor of N-acetylated alpha-linked acidic dipeptidase (NAALADase), which hydrolyzes endogenous NAAG into N-acetyl-aspartate and glutamate, significantly reduced neonatal hypoxia-ischemia-induced brain injury. "
4.	Seizures (Absence Seizure) 02/02/1996 - "1S,3R-ACPD (200 nmol) injected into the amygdala (AM) of non-kindled rats produced immediate and transient seizures, characterized by immobility, searching, and wet-dog shakes. " 03/01/1995 - "Both doses of 1S,3R-ACPD produced seizures in animals that were characterized by multiple episodes of wet dog shakes, staring, immobility, facial automatisms, rearing, bilateral forelimb clonus, and loss of postural control. " 11/12/1993 - "Injections of 1S,3R-ACPD (50-800 nmol in 5 microliters) into the thalamus produced a dose-dependent increase in limbic seizures. " 02/01/1998 - "In conclusion, the in vivo activation of group I mGluRs with the selective agonist 3,5-DHPG produces hyperexcitatory effects that lead to seizures and neuronal damage, these effects being more severe than those observed after infusion of the non-selective agonist 1S,3R-ACPD." 02/02/1996 - "Intra-AM injection of 1S,3R-ACPD (40 or 200 nmol) or L-AP4 (200 nmol) resulted in a delayed and marked suppression of kindled seizures, 3 days after 40 nmol of 1S,3R-ACPD, 1 day after 200 nmol of 1S,3R-ACPD, and from 1 to 3 days after 200 nmol of L-AP4. "
5.	Substance Withdrawal Syndrome (Withdrawal Symptoms) 06/01/1997 - "2. In the present study, we showed that acute i.c.v. administration of the non-selective mGluR agonist 1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD), as well as the group II selective agonist (2S,1'R,2'R,3'R)-2-(2'.3'-dicarboxycyclopropyl)glycine (DCG-IV), significantly attenuated the severity of precipitated withdrawal symptoms. "

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Acids
3.	Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)
4.	Cyclopentanes (Cyclopentane)
5.	N-acetylaspartate (N-acetyl aspartate)
6.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
7.	Calcium
8.	2-(2,3-dicarboxycyclopropyl)glycine
9.	N-Methylaspartate (NMDA)
10.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)

Related Therapies and Procedures

1.	Spinal Injections
2.	Injections
3.	Intravenous Injections
4.	Oral Administration