N-nitroso-N-methyltyramine (NNMT)

11/01/2021 - "5-amino-1-methylquinolinium (5MQ) is a novel small molecule inhibitor of NNMT that has shown promising results in the treatment of obesity and in senescent muscle regeneration. "
06/01/2023 - "Several studies have suggested that the overexpression of NNMT is associated with different metabolic disorders like obesity and type-2 diabetes thereby making it an important therapeutic target for development of anti-diabetic agents. "
02/01/2018 - "The aim of this study was to analyze NNMT activity in tissues of mice with incipient and established obesity. "
01/01/2021 - "Evidence has shown that NNMT is associated with obesity and T2D. "
05/01/2020 - "NNMT expression in adipose tissue is increased in obesity and diabetes. "

01/01/2023 - "Treatment with an NNMT inhibitor improved renal tubular interstitial fibrosis, and expression levels of FN, α-SMA, VIM, and TGF-β1 were decreased compared with UUO (P < 0.05). "
01/01/2022 - "We generated NNMT-deficient mice and a unilateral ureter obstruction (UUO) model and conducted two clinical studies on human CKD to investigate the role of NNMT in CKD and fibrosis. "
01/01/2023 - "We propose that NNMT promotes fibroblast activation and renal fibrosis, making NNMT a novel target for preventing and treating renal fibrosis."
01/01/2023 - "Additionally, NNMT was positively correlated with the expression of renal fibrosis-related genes after UUO injury. "
01/01/2023 - "In the validation group, NNMT levels were significantly higher in the CKD group combined with interstitial fibrosis. "

01/01/2020 - "This study aims to investigate the effect of NNMT on autophagy induced by oxidative stress in breast cancer cells, which might provide a novel therapeutic strategy for breast cancer treatment. "
01/01/2023 - "In line, NNMT expression is associated with poor clinical outcomes in patients with breast cancer. "
01/01/2020 - "We conclude that NNMT inhibits the autophagy induced by oxidative stress through the ROS-mediated AMPK-ULK1 pathway in breast cancer cells and may protect breast cancer cells against oxidative stress through autophagy suppression."
01/01/2019 - "The effects of NNMT on chemoresistance in breast cancer cells were assessed by cell viability, colony formation, and apoptosis assay. "
01/01/2019 - "NNMT expression in breast carcinoma was examined by immunohistochemistry, and then, its relationship with patient clinicopathological characteristics was analyzed. "

07/01/2018 - "Interestingly, the adipose tissue NNMT gene expression correlated with markers of adipose tissue inflammation. "
05/01/2010 - "Because MNA displays PGI(2)-dependent anti-inflammatory effects, the up-regulation of NNMT may play a regulatory role in liver inflammation. "
01/01/2009 - "In summary, the present study demonstrated that the progression of vascular inflammation and atherosclerosis was associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous MNA plasma levels. "
07/01/2018 - "The expression of FBXO21 and FOXK2 was specifically modified after weight loss concomitantly with a decrease in NNMT expression and inflammation-related genes. "
05/01/2022 - "An exogenous increase of methylnicotinamide, a metabolite produced by nicotinamide N-methyltransferase (NNMT), has anti-inflammatory effects, but it is not clear whether NNMT has the same effect, and the role of NNMT in DON-induced inflammation and growth impairment remains indistinct. "

01/01/2019 - "Although NNMT-/- mice fed a standard diet had no obvious phenotype, NNMT-/- males fed an HFD showed strongly improved insulin sensitivity (IS). "
01/01/2018 - "Comparison of our results to a study on human visceral fat of obese non-diabetic and obese diabetic subjects, indicated that AUH, NAGK, pCYT2, NNMT, STK39 and CSNK2A2 might indeed be linked to insulin resistance in humans. "
04/01/2015 - "Interventions improving insulin sensitivity--exercise and bariatric surgery--were associated with a significant (p < 0.001) reduction in WAT NNMT expression. "
05/01/2020 - "Knockdown of NNMT prevents mice from developing diet-induced obesity, which is closely linked to insulin resistance. "
01/01/2022 - "Nicotinamide N-methyltransferase (NNMT) is a methylase, and its expression is positively correlated with obesity and insulin resistance. "