|1.||Emanuelli, Monica: 8 articles (03/2015 - 07/2007)|
|2.||Sartini, Davide: 8 articles (03/2015 - 07/2007)|
|3.||Pozzi, Valentina: 7 articles (03/2015 - 01/2010)|
|4.||Parsons, Richard B: 6 articles (11/2015 - 02/2002)|
|5.||Ramsden, David B: 6 articles (11/2015 - 02/2002)|
|6.||Rubini, Corrado: 6 articles (03/2015 - 07/2007)|
|7.||Morganti, Stefano: 5 articles (03/2015 - 05/2012)|
|8.||Santarelli, Andrea: 4 articles (01/2013 - 07/2007)|
|9.||Lo Muzio, Lorenzo: 4 articles (01/2013 - 07/2007)|
|10.||Zhang, Jun: 3 articles (12/2014 - 02/2010)|
01/01/2013 - "Further studies may establish whether NNMT could represent a target for an effective anti-cancer therapy. "
05/15/2011 - "Furthermore, the results of the present study also raise the possibility of using inhibitors of NNMT for the treatment of cancer."
01/01/2009 - "The results of this study indicated that NNMT gene expression is associated with tumor stage and DFS time in HCC cases. "
05/01/2013 - "NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink."
03/15/2013 - "As such, inhibition of NNMT activity is a promising therapeutic target for cancer therapy. "
|2.||Parkinson Disease (Parkinson's Disease)
07/01/2005 - "Further study is needed to clarify the reason why the effects of Mn(2+) and Fe(2+) which have a high relevance to Parkinson's disease on NNMT activity differ from those of Cu(2+) and Cd(2+)."
12/01/2000 - "Further study on the mechanism underlying increase in nNMT activity in parkinsonian patients will clarify the involvement of genetic and environmental factors in the pathogenesis of Parkinson's disease."
05/15/2011 - "NNMT expression is significantly elevated in a number of cancers, and we have previously demonstrated that NNMT expression is significantly increased in the brains of patients who have died of Parkinson's disease. "
02/01/2002 - "Nicotinamide N-methyltransferase (NNMT) has been proposed as a link between the environmental and genetic factors of Parkinson disease (PD). "
11/20/2015 - "We have previously shown that NNMT is significantly overexpressed in the brains of patients who have died of Parkinson's disease, and others have shown that NNMT is significantly overexpressed in a variety of diseases ranging from cancer to hepatic cirrhosis. "
|3.||Schizophrenia (Dementia Praecox)
07/01/2012 - "Our study favours the notion that NNMT is involved in the aetiology of schizophrenia."
07/01/2012 - "This is the first study demonstrating an association of NNMT with schizophrenia. "
01/01/2014 - "Female specific association between NNMT gene and schizophrenia in a Han Chinese population."
07/01/2012 - "Aiming to assess the possible involvement of NNMT in the aetiology of schizophrenia we (1) performed an association study of eight NNMT tagged SNPs in 202 families sharing the same ethnic origin including healthy parents and a schizophrenia proband; (2) assessed NNMT mRNA levels in post-mortem frontal cortex of schizophrenia patients. "
07/01/2011 - "A recent study carried out by the authors of this paper found an association between NNMT and schizophrenia and decreased post-mortem brain NNMT mRNA levels. "
08/01/2015 - "This first large-scale population study shows that me-NAM, as an indicator of NNMT activity, is strongly associated with obesity and diabetes, supporting NNMT as a potential target for treating obesity and diabetes in humans."
08/01/2015 - "However, whether NNMT plays a role in human obesity and type 2 diabetes (T2DM) remains to be elucidated. "
04/10/2014 - "Nnmt knockdown in WAT and liver protects against diet-induced obesity by augmenting cellular energy expenditure. "
04/01/2015 - "Nicotinamide-N-methyltransferase (NNMT) was recently shown to be upregulated in mouse models of insulin resistance and obesity. "
08/01/2015 - "Nicotinamide N-methyltransferase (NNMT) is a novel histone methylation modulator that regulates energy metabolism, and NNMT knockdown prevents diet-induced obesity in mice. "
|5.||Colorectal Neoplasms (Colorectal Cancer)
12/15/2014 - "In the present study, we investigated the effects of NNMT on tumorigenesis by overexpressing NNMT in the human colorectal cancer cells line SW480 which lacks constitutive NNMT expression, and downregulating NNMT expression in HT-29 cells, which exhibit high endogenous expression of NNMT. "
12/15/2014 - "However, the biological function of NNMT and the related mechanisms in colorectal cancer have not been elucidated. "
09/15/2005 - "It is proposed that NNMT serum levels may have significance in the early detection and in the management of patients with colorectal cancer."
09/15/2005 - "Elevated levels of NNMT, which is not predicted to be secreted but is known as a cytoplasmic protein, were found in serum from patients with colorectal cancer. "
12/15/2014 - "Our results indicate that NNMT enhances the capacity of tumorigenesis associated with the inhibition of cell apoptosis and the promotion of cell cycle progression in human colorectal cancer cells and the 1-methylnicotinamide increased by NNMT mediates the cellular effects of NNMT in cells. "
|3.||Messenger RNA (mRNA)
|4.||Small Interfering RNA (siRNA)
|6.||Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
|10.||Apolipoproteins E (ApoE)
|1.||Heterologous Transplantation (Xenotransplantation)