gastrin I

heptadecapeptide amide, H-Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
Networked: 21 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1. Zollinger-Ellison Syndrome (Syndrome, Zollinger-Ellison)
02/01/1972 - "A perfused rat stomach technique which can detect synthetic human gastrin I in amounts greater than 10 ng and measure by block assay amounts greater than 50 ng was used to study circulating gastrin-like activity in normal subjects, patients with peptic ulcer, and patients with the Zollinger-Ellison syndrome. "
07/01/1968 - "Production of antibodies to synthetic human gastrin I and radioimmunoassay of gastrin in the serum of patients with the zollinger-ellison syndrome."
01/01/1972 - "1. A radio-immunoassay for gastrin has been developed using partially purified porcine gastrin to raise antibodies and highly purified natural porcine gastrin I for radio-iodination with (125)I. The separation of antibody-bound from free hormone was performed by a double-antibody method.2. In this assay highly purified natural porcine gastrin I, synthetic human gastrin I, radio-iodinated porcine gastrin I, gastrin in the plasma of a healthy volunteer, a patient with pernicious anaemia and another patient with the Zollinger-Ellison syndrome were immunologically identical.3. The fasting plasma gastrin concentration of fourteen gastric ulcer patients was significantly higher than that of the 113 hospital controls with no history of gastro-intestinal disease, while twenty-seven duodenal ulcer patients had gastrin levels within the normal range.4. Plasma gastrin concentration was significantly elevated in pernicious anaemia (fifty-one patients), achlorhydria (thirty-three patients), hypochlorhydria (eleven patients) and in nine patients with histologically proven Zollinger-Ellison syndrome.5. In human volunteers a protein meal stimulated endogenous gastrin release while a carbohydrate meal did not. "
2. Peptic Ulcer (Peptic Ulcers)
3. Fistula
4. Carcinoid Tumor (Carcinoid)
5. Esophageal Achalasia (Megaesophagus)

Related Drugs and Biologics

1. Gastrins
2. Histamine (Histamine Dihydrochloride)
3. Pentagastrin (Peptavlon)
4. Secretin
5. Antibodies
6. Cholecystokinin B Receptor
7. Methacholine Chloride (Methacholine)
8. Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))
9. Thymidine
10. Staphylococcal Protein A (A, Protein)

Related Therapies and Procedures

1. Catheters
2. Vagotomy
3. Intraperitoneal Injections
4. Intravenous Infusions