|1.||Chapouthier, G: 3 articles (11/2001 - 07/2000)|
|2.||Martin, B: 2 articles (11/2001 - 07/2000)|
|3.||Rinaldi, D: 2 articles (11/2001 - 12/2000)|
|4.||Venault, P: 2 articles (12/2000 - 07/2000)|
|5.||Tufik, Sergio: 1 article (01/2010)|
|6.||Moreira, Karin Di Monteiro: 1 article (01/2010)|
|7.||Nobrega, José N: 1 article (01/2010)|
|8.||Dubiela, Francisco Paulino: 1 article (01/2010)|
|9.||Oliveira, Maria Gabriela Menezes de: 1 article (01/2010)|
|10.||Hipólide, Débora Cristina: 1 article (01/2010)|
11/01/2001 - "An absence of genetic correlation was found, showing that the mechanisms responsible for basal anxiety measured with the elevated plus-maze test and those leading to susceptibility to beta-CCM-induced seizures do not share the same genetic pathways."
11/01/2001 - "Since these molecules have influences on both anxiety and convulsions, we predicted that there would exist a genetic correlation between anxiety evaluated in an elevated plus-maze and susceptibility to beta-CCM-induced seizures. "
12/01/2000 - "BR is highly resistant, and BS, highly sensitive to beta-CCM-induced seizures. "
07/14/2000 - "We provided evidence for the involvement of a fragment of mouse chromosomes 4 and 13 in beta-CCM-induced seizures in a previous paper. "
05/15/1999 - "By measuring the latency to generalized seizures after beta-CCM administration to A/J and C57BL6/J mice and their progeny, we estimated a heritability of 0.28 +/- 0.10. "
|2.||Muscle Spasticity (Spastic)
07/17/1985 - "Effects of methyl beta-carboline-3-carboxylate, Ro 15-1788 and CGS 8216 on muscle tone in genetically spastic rats."
07/17/1985 - "beta-CCM, 2.5 and 3.0 mg/kg i.p., augmented the tonic activity in the EMG of GS muscle in spastic rats while it did not modify muscle tone at doses of 1.0 and 2.0 mg/kg. Diazepam, 0.4 mg/kg i.p., and Ro 15-1788, 5 mg/kg i.p., but not CGS 8216, 5 mg/kg i.p., antagonised the effect of the beta-carboline on muscle tone. "
07/17/1985 - "Genetically spastic rats were used for studying the effect on muscle tone of beta-carboline-3-carboxylic acid methylester (beta-CCM), an inverse benzodiazepine (BDZ) agonist, and that of Ro 15-1788 and CGS 8216, both putative antagonists of pharmacological actions of BDZs. "
08/22/1986 - "Beta-Carboline-3-carboxylic acid methylester (beta-CCM), 2 mg/kg i.p., while not affecting the tonic activity in the EMG, reversed the depressant effect of phenobarbitone, 30 mg/kg. Both Ro 15-1788, 5 mg/kg, and CGS 8216, 5 mg/kg, prevented the reversal of the depressant action of phenobarbitone, 30 mg/kg, produced by beta-CCM, 2 mg/kg. The results indicate that the muscle relaxant action of phenobarbitone in genetically spastic rats is mediated via GABA-related mechanisms and add further support to the hypothesis that both Ro 15-1788 and CGS 8216 are specific antagonists at benzodiazepine receptors, devoid of intrinsic activity at moderate doses. "
|4.||Reflex Epilepsy (Photosensitive Epilepsy)
09/03/1984 - "The proconvulsant and convulsant actions of methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) and of methyl-beta-carboline-3-carboxylate (beta-CCM) have been evaluated in two animal models of reflex epilepsy, the photosensitive baboon, Papio papio, and the audiogenic seizure prone DBA/2 mouse. "
|5.||Androgen-Insensitivity Syndrome (Testicular Feminization)
|1.||methyl 6,7- dimethoxy- 4- ethyl- beta- carboline- 3- carboxylate
|2.||GABA-A Receptors (GABA(A) Receptor)
|3.||gamma-Aminobutyric Acid (GABA)