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procymidone

Also Known As:

(3,5-dichlorophenyl)-1,2-dimethylcyclopropane-1,2-dicarboximide; Procymidox; S-7131; Sumilex; Sumisclex; dicyclidine

Networked: 14 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Bridged-Ring Compounds: 1
      - Bridged Bicyclo Compounds
        procymidone: 14
Polycyclic Compounds: 6
- Bridged-Ring Compounds: 1
  - Bridged Bicyclo Compounds
    - procymidone: 14

Experts

1.	Li, Xinghai: 1 article (01/2022)
2.	Peng, Jingnan: 1 article (01/2022)
3.	Qi, Zhiqiu: 1 article (01/2022)
4.	Wang, Kai: 1 article (01/2022)
5.	Wang, Yingzi: 1 article (01/2022)
6.	Zhang, Huazhong: 1 article (01/2022)
7.	Zhu, Wanying: 1 article (01/2022)
8.	Fu, Hu: 1 article (01/2022)
9.	Li, Rui: 1 article (01/2022)
10.	Wang, Qing: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 06/19/2003 - "Although chronic administration of procymidone (a widely used dicarboximide fungicide) leads to an increased incidence of liver tumors in mice, short-term genotoxicity studies proved negative. " 04/01/1995 - "To clarify the mechanism of species difference in the induction of testicular interstitial cell tumor (ICT, Leydig cell tumor) between rats and mice, male Sprague-Dawley rats and ICR mice were fed procymidone at dietary concentrations of 700, 2000 or 6000 ppm and 1000, 5000, or 10,000 ppm, respectively, for 3 months. " 05/01/1993 - "To investigate the mechanism and toxicological significance of testicular interstitial cell tumors (ICT) observed in a long-term rat study with procymidone, N-(3,5-dichlorophenyl)-1,2-dimethylcyclopropane-1,2-dicarboximi de, male Sprague-Dawley rats were fed procymidone in diets for up to 6 months with a positive control group receiving a single subcutaneous injection of cadmium chloride. "
2.	Carcinogenesis 06/19/2003 - "These data may explain why in vitro short-term genotoxicity studies on procymidone were negative, whereas in vivo long-term carcinogenesis studies turned out positive: long-term CYP induction (e.g. " 04/01/1995 - "These differences in the response of interstitial cells to procymidone may be the basis for the distinct species responses to procymidone-induced Leydig cell tumorigenesis. " 04/01/1995 - "Species-specific mechanism in rat Leydig cell tumorigenesis by procymidone." 06/19/2003 - "As cytochrome P450 (CYP) induction has been linked to non-genotoxic carcinogenesis, we investigated whether procymidone administration causes induction of CYP-dependent monooxygenases in liver, kidney and lung microsomes of male Swiss Albino CD1 mice after single or repeated (daily for three consecutive days) i.p. "
3.	Branchiootic syndrome 05/01/2010 - "In the present study, the complete two-component histidine kinase gene (Bos1) was sequenced for 10 procymidone-resistant and 3 procymidone-sensitive B. " 01/29/2022 - "Moreover, the cell membrane functions of B.cinerea, histidine kinase activity, relative conductivity, triglyceride, and cell membrane structure were determined, and the target gene histidine kinase Bos1 (AF396827.2) of procymidone was amplified and sequenced. " 05/01/2010 - "Isolates representing four different procymidone-resistant phenotypes (CarRDieSPrcRPyrS, CarRDieRPrcRPyrS, CarRDieRPrcRPyrR, and CarRDieRPrcRPyrR) all had nucleic acid point mutations resulting in amino acid changes at position 369 (change from glutamine to proline) as well as at amino acid position 373 (asparagine to serine) in the Bos1 gene."
4.	Cicatrix (Scar) 11/01/2023 - "Procymidone (PCM) below the no-observed-adverse-effect-level (NOAEL) has previously been proven to induce ovarian and uterine damage in adolescent mice due to its raised circRNA Scar, decreased circZc3h4, and overactivated unfolded protein response (UPR). " 11/01/2022 - "The joint action of unfolded protein response, circZc3h4, and circRNA Scar in procymidone-induced testicular injury in adolescent mice." 01/01/2022 - "Combined effect of unfolded protein response and circZc3h4, circRNA Scar in mouse ovary and uterus damage induced by procymidone." 11/01/2023 - "4-Phenylbutyric acid may prevent mouse ovarian and uterine damage due to procymidone-induced alteration of circRNA Scar and circZc3h4 levels by controlling excessive unfolded protein response."
5.	Weight Loss (Weight Reduction) 02/01/2003 - "Dosing the animals with a combination of a 1:1 mixture of vinclozolin and procymidone resulted in a weight reduction in the reproductive organs and an increase of serum LH and FSH as early as with 10 mg/kg combined dose. "

Related Drugs and Biologics

1.	Histidine Kinase
2.	Cadmium Chloride (Cadmium Dichloride)
3.	Circular RNA
4.	vinclozolin
5.	Finasteride (Propecia)
6.	Triglycerides (Triacylglycerol)
7.	Testosterone (Sustanon)
8.	Serine (L-Serine)
9.	Proline (L-Proline)
10.	Nucleic Acids

Related Therapies and Procedures

1.	Subcutaneous Injections