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benz(c)acridine

Also Known As:

3,4-benzacridine

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - benz(c)acridine: 5

Experts

1.	Gálfi, M: 1 article (12/2000)
2.	Gáspár, L: 1 article (12/2000)
3.	Juhász, A: 1 article (12/2000)
4.	Julesz, J: 1 article (12/2000)
5.	Khalil, W K: 1 article (12/2000)
6.	Molnár, J: 1 article (12/2000)
7.	Valkusz, Z: 1 article (12/2000)
8.	LaVoie, E J: 1 article (05/2000)
9.	Liu, A: 1 article (05/2000)
10.	Liu, L F: 1 article (05/2000)

Related Diseases

1.	Poisoning 05/01/2000 - "While the benz[c]acridine derivatives evaluated as part of this study were devoid of topoisomerase poisoning activity, several dihydrobenz[a]acridines were able to enhance DNA cleavage in the presence of topo I. In contrast to certain protoberberine derivatives that did exhibit activity as topo II poisons, none of the benz[a]acridines derivatives enhanced DNA cleavage in the presence of topo II. Among the benz[a]acridines studied, 5,6-dihydro-3,4-methylenedioxy-9,10-dimethoxybenz[a]acridine, 13e, was the most potent topo I poison, with comparable potency to coralyne. "
2.	Neoplasms (Cancer) 10/01/1983 - "Tumor-initiating activity of benz[c]acridine and twelve of its derivatives on mouse skin." 09/01/1986 - "This latter result indicates that substitution of a methyl group at position 7 of benz[c]acridine leads to enhanced tumor-initiating activity, as has been previously demonstrated for benz[a]anthracene and its 7-methyl derivative." 10/01/1983 - "Benz[c]acridine (B[c]ACR) and 12 of its derivatives, including the 5 metabolically possible trans-dihydrodiols, the diastereomeric bay-region diol-epoxides, 2 non-bay-region diol-epoxides, and the K-region arene oxide, were tested for tumor-initiating activity on mouse skin. "
3.	Prolactinoma (Prolactinomas) 12/01/2000 - "The ATP-ase activities were highly increased in benz(c)acridine-treated cells and in estrogen-induced prolactinoma cells, more strongly so in the former ones. "
4.	Adenoma (Adenomas) 03/01/1980 - "Some potential polynuclear electrophiles, including chloromethyl derivatives of acridine and benz(c)acridine, a hydroxymethyl and an acetoxymethyl derivative of benz(a)anthracene, an acetoxymethylanthracene, and an acridinylglycine ester, were found not to be carcinogenic in the lung adenoma test."

Related Drugs and Biologics

1.	Acridines
2.	Poisons
3.	trioctyl phosphine oxide (TOPO)
4.	protoberberine
5.	coralyne
6.	benz(a)anthracene (benzanthracene)
7.	Oxides
8.	Estrogens (Estrogen)
9.	Esters
10.	Epoxy Compounds (Epoxides)