cefbuperazone (T 1982)

RN given refers to parent cpd(6R-(6alpha,7alpha,7(2R*,3S*)))-isomer; structure

Also Known As:

T 1982; T-1982; cefbuperazone sodium, (6R-(6alpha,7alpha,7(2R*,3S*)))-isomer; sodium 7beta-(2R, 3S)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-(3-hydroxybutanamido)-7alpha-methoxy-3-((1-methyl-1H-tetrazol-5-yl)thiomethyl)-3-cephem-4-carboxylate; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((2-(((4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl)amino)-3-hydroxy-1-oxobutyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7alpha,7(2R*,3S*)))-

Networked: 61 relevant articles (7 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Drug Allergy Work Group of KAAACI: 1 article (09/2021)
2.	Jung, Jae-Woo: 1 article (09/2021)
3.	Kang, Dong-Yoon: 1 article (09/2021)
4.	Kang, Hye-Ryun: 1 article (09/2021)
5.	Kim, Sujeong: 1 article (09/2021)
6.	Nam, Young-Hee: 1 article (09/2021)
7.	Park, Chan Sun: 1 article (09/2021)
8.	Park, Hye Jung: 1 article (09/2021)
9.	Park, Hye-Kyung: 1 article (09/2021)
10.	Park, So-Young: 1 article (09/2021)

Related Diseases

1.	Infections 05/01/1983 - "Ten cases of gynecological infections receiving T-1982 demonstrated "good" results in 9 cases, except 1 case excluded from the evaluation of efficacy. " 05/01/1983 - "Judging from its favorable transfer into the uterine tissues and MICs against clinical isolates often seen in the field of obstetrics and gynecology, T-1982 was evaluated to be clinically useful in the treatment of obstetrical and gynecological infections." 05/01/1983 - "These results suggest that T-1982 has efficacy for the treatment of obstetrical and gynecological infections." 03/01/1988 - "We conducted clinical studies on the efficacy and safety of cefbuperazone (CBPZ) on surgical infections with the following results. " 03/01/1988 - "[Clinical studies on effect of cefbuperazone on surgical infections]."
2.	Bacterial Infections (Bacterial Infection) 05/01/1983 - "These results suggest that T-1982 is highly effective for the treatment of bacterial infections in this field." 04/01/1983 - "T-1982 was effective in 13 cases out of 13 cases with bacterial infections. " 05/01/1983 - "Eleven patients with bacterial infections were treated with T-1982. " 04/01/1983 - "4. These results suggest that T-1982 is of good use for bacterial infections in children and the expected efficacy is obtained at a dose of 20 mg/kg 3 times a day." 04/01/1983 - "The data suggest that T-1982 is an effective and safe parenteral antibiotic in the treatment of susceptible pediatric bacterial infections."
3.	Pelvic Inflammatory Disease (Pelvic Inflammatory Diseases) 05/01/1983 - "A total of 10 cases comprising 1 with intrauterine infection, 2 with pelveoperitonitis, 2 with adnexitis and 5 with external genital organ infection were intravenously treated with T-1982 at a dose of 1 g twice daily for 5-7 days. " 05/01/1983 - "Clinical study T-1982 was administered to 2 cases with pelveoperitonitis, 2 cases with puerperal fever and 1 case with adnexitis at a dose of 1 g twice a day for a period of 4 or 5 days. " 05/01/1983 - "When T-1982 was administered at a dose of 1-2 g twice a day to 14 patients with female genital infection; 2 intrauterine infection, 2 pyometra, 7 pelveoperitonitis, 1 adnexitis, 1 adnexal abscess and 1 vaginal cuff abscess, the clinical results were excellent in 9, effective in 4 and poor in 1. The efficacy rate was 92.9%. " 05/01/1983 - "T-1982 was administered to 11 patients, including 7 of acute adnexitis, each one of pelveoperitonitis, pyometra, puerperal fever, and 1 of puerperal fever with sepsis, at a dose of 1-2 g twice a day for a period of 5 to 9 days by intravenous injection or intravenous drip infusion. " 05/01/1983 - "T-1982 was administered to 17 cases: 6 cases of parametritis, 3 cases of endometritis after artificial abortion, 3 cases of puerperal fever, 2 cases of febrile abortion, 1 case of Bartholin's abscess, 1 case of adnexitis and 1 case of infection of vaginal hematoma. "
4.	Pyometra 05/01/1983 - "With its MIC values, T-1982 was considered to be bactericidal against many Gram-negative bacteria except Pseudomonas sp. A total of 4 cases comprising 2 with pyometra, 1 with pelveoperitonitis and 1 with endometritis complicated with pelveoperitonitis was treated with T-1982 at a dose of 1-2 g twice daily by intravenous drip infusion. " 05/01/1983 - "In a clinical study, T-1982 was given to 5 patients; 2 patients with parametritis and each one patient with right salpingitis, pyometra and metroendometritis. " 05/01/1983 - "When T-1982 was administered at a dose of 1-2 g twice a day to 14 patients with female genital infection; 2 intrauterine infection, 2 pyometra, 7 pelveoperitonitis, 1 adnexitis, 1 adnexal abscess and 1 vaginal cuff abscess, the clinical results were excellent in 9, effective in 4 and poor in 1. The efficacy rate was 92.9%. " 05/01/1983 - "T-1982 was administered to 11 patients, including 7 of acute adnexitis, each one of pelveoperitonitis, pyometra, puerperal fever, and 1 of puerperal fever with sepsis, at a dose of 1-2 g twice a day for a period of 5 to 9 days by intravenous injection or intravenous drip infusion. "
5.	Abscess 05/01/1983 - "When T-1982 was administered at a dose of 1-2 g twice a day to 14 patients with female genital infection; 2 intrauterine infection, 2 pyometra, 7 pelveoperitonitis, 1 adnexitis, 1 adnexal abscess and 1 vaginal cuff abscess, the clinical results were excellent in 9, effective in 4 and poor in 1. The efficacy rate was 92.9%. " 05/01/1983 - "T-1982 was administered to 17 cases: 6 cases of parametritis, 3 cases of endometritis after artificial abortion, 3 cases of puerperal fever, 2 cases of febrile abortion, 1 case of Bartholin's abscess, 1 case of adnexitis and 1 case of infection of vaginal hematoma. " 04/01/1983 - "3. Treatment with T-1982 was made in 28 cases of pediatric infections; 1 case of acute bronchitis, 19 cases of acute bronchopneumonia or lobar pneumonia, 2 cases of acute purulent cervical lymphadenitis, 4 cases of acute pyelonephritis and each 1 case of subcutaneous abscess and suspected bacterial endocarditis. " 04/01/1983 - "T-1982 (cefbuperazone) was given intravenously to 21 children with the following acute bacterial infections; 13 cases of bronchopneumonia, 2 cases of urinary tract infection, 1 case of subcutaneous abscess, 1 case of cervical purulent lymphadenitis and acute tonsillitis, and 4 cases of acute bronchitis. "

Related Drugs and Biologics

1.	cefbuperazone (T 1982)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Sodium
4.	Therapeutic Uses
5.	Cefotetan (Cefotan)
6.	Cefoperazone (Cefoperazone Sodium)
7.	Cefmenoxime (Cefmax)
8.	Ceftriaxone (Ceftriaxon)
9.	Cefazolin (Ancef)
10.	cefpiramide

Related Therapies and Procedures

1.	Thyroidectomy
2.	Mastectomy (Mammectomy)
3.	Intravenous Infusions
4.	Hysterectomy
5.	Intravenous Injections