trequinsin

RN given refers to parent cpd; structure given in first source

Also Known As:

2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl-2-((2,4,6-trimethylphenyl)imino)-4H-pyrimido(6,1-a)isoquinolin-4-one, monohydrochloride; HL 725; HL-725; trequinsin hydrochloride

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Tetrahydroisoquinolines: 44
        trequinsin: 3

Experts

1.	Kopanitsa, Liliya: 2 articles (09/2021 - 01/2020)
2.	Ladds, Graham: 2 articles (09/2021 - 01/2020)
3.	Safitri, Dewi: 2 articles (09/2021 - 01/2020)
4.	Bailey, David S: 1 article (09/2021)
5.	Kopanitsa, Maksym V: 1 article (09/2021)
6.	Bailey, David: 1 article (01/2020)
7.	Harper, Matthew T: 1 article (01/2020)
8.	Harris, Matthew: 1 article (01/2020)
9.	Potter, Harriet: 1 article (01/2020)
10.	Rahman, Taufiq: 1 article (01/2020)

Related Diseases

1.	Sudden Death 06/01/1987 - "This study was designed to determine the in vivo effects of a phosphodiesterase inhibitor (HL 725) in combination with a thromboxane synthase inhibitor (CGS 13080) or prostacyclin (PGI2) as inhibitors of thrombin-induced changes in platelet function and prevention of sudden death. "
2.	Thrombosis (Thrombus) 06/01/1987 - "In anesthetized rabbits, the i.v. administration of thrombin reduced the circulating number of platelets from 256,000 +/- 32,000/microliter to 8 +/- 2% of the initial value, and produced a right ventricular thrombus of 285 +/- 52 mg. All animals died within 5 min. PGI2 (0.3 microgram/kg/min) or HL 725 (2 micrograms/kg/min) did not prevent the thrombin-induced fall in the number of circulating platelets, the formation of a right ventricular thrombus or death. " 06/01/1987 - "After the administration of the combination of CGS 13080 with HL 725, the thrombocytopenia was transient, the right ventricular thrombus was reduced (P less than .05), and survival increased to 75% (P less than .05). "
3.	Thrombocytopenia (Thrombopenia) 06/01/1987 - "After the administration of the combination of CGS 13080 with HL 725, the thrombocytopenia was transient, the right ventricular thrombus was reduced (P less than .05), and survival increased to 75% (P less than .05). "
4.	Glioblastoma (Glioblastoma Multiforme) 09/07/2021 - "The PDE10A inhibitors PF-2545920, PQ10 and papaverine, the PDE3/4 inhibitor trequinsin and the putative PDE5 inhibitor MY-5445 potently decreased glioblastoma cell proliferation. "
5.	Aneuploidy (Aneuploid) 01/01/2020 - "In contrast, trequinsin (a non-selective PDE2/3/7 inhibitor), not only inhibited cell growth via PKA, but also stimulated (independent of PKA) caspase-3/-7 and induced an aneuploidy phenotype. "

Related Drugs and Biologics

1.	Thromboxanes
2.	Thrombin
3.	Epoprostenol (Prostacyclin)
4.	Phosphodiesterase Inhibitors
5.	pirmagrel
6.	Phosphodiesterase 5 Inhibitors
7.	Caspase 3 (Caspase-3)
8.	Papaverine
9.	2- ((4- (1- methyl- 4- pyridin- 4- yl- 1H- pyrazol- 3- yl)phenoxy)methyl)quinoline
10.	MY 5445