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fosfedil
structure
Also Known As:
Abbott 53986; KB 944; KB-944; diethyl 4-(benzothiazol-2-yl)benzylphosphonate; fostedil; Phosphonic acid, ((4-(2-benzothiazolyl)phenyl)methyl)-, diethyl ester
Networked:
8
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Thiazoles: 392
Benzothiazoles: 40
fosfedil: 8
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzothiazoles: 40
fosfedil: 8
Related Diseases
1.
Tachycardia (Tachyarrhythmias)
09/01/1984 - "
An examination of the temporal profiles of the cardiac electrophysiologic effects of KB-944 indicated selective alterations in AV nodal conduction and refractoriness for durations of approximately 60, 120 and 180 to 240 min after administration of 0.3, 1.0 or 3.0 mg/kg i.v. These results suggest that KB-944 may be an effective agent for treatment of supraventricular tachyarrhythmias via selective depression of the AV nodal conduction system.
"
2.
Angina Pectoris
11/01/1985 - "
The anti-anginal effects of KB-944 (Fostedil), a new calcium ion antagonist with a half life of approximately 23-28 hr, were evaluated in 20 patients with exertional angina pectoris in a placebo-controlled single-blind dose titration trial.
"
11/01/1985 - "
Ambulatory monitoring and exercise testing in the evaluation of a new long-acting calcium ion antagonist KB-944 (Fostedil) for the treatment of exertional angina pectoris.
"
3.
Atrioventricular Block
05/01/1983 - "
In atrioventricular (AV) node preparations KB-944 increased AV conduction time and in large doses produced second- or third-degree AV block only when injected into the artery supplying the AV node.
"
4.
Lethargy
11/01/1985 - "
Five patients complained of dyspepsia and one of headache and lethargy during KB-944 200 mg/day.
"
5.
Myocardial Ischemia (Ischemic Heart Diseases)
07/01/1986 - "
Effects of KB-944, a novel calcium antagonist, in several models of canine myocardial ischemia.
"
Related Drugs and Biologics
1.
fosfedil
2.
Calcium
3.
Diltiazem (Cardizem)
4.
Bepridil (Vascor)
5.
Vasodilator Agents (Vasodilators)
6.
Urethane (Ethyl Carbamate)
7.
Papaverine