dauricine

RN given refers to parent cpd

Also Known As:

4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)-2-(4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)phenoxy)phenol; dauricine monohydrochloride

Networked: 50 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzylisoquinolines: 151
    - dauricine: 50
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Benzylisoquinolines: 151
        dauricine: 50
      - Tetrahydroisoquinolines: 44
        dauricine: 50

Experts

1.	Chen, Wei: 6 articles (01/2022 - 11/2018)
2.	Wang, Lingfeng: 5 articles (12/2021 - 11/2018)
3.	Gong, Pei-Li: 5 articles (01/2010 - 01/2007)
4.	Wang, Kaixuan: 4 articles (01/2022 - 02/2020)
5.	Pu, Zhijun: 4 articles (01/2022 - 11/2018)
6.	Li, Mingxin: 4 articles (04/2020 - 11/2018)
7.	Zhang, Li: 4 articles (01/2010 - 01/2007)
8.	Luo, Yunfeng: 3 articles (01/2022 - 11/2018)
9.	Liu, Qiang-Ni: 3 articles (01/2010 - 01/2007)
10.	Yang, Xiao-Yan: 3 articles (01/2010 - 01/2007)

Related Diseases

1.	Cognitive Dysfunction 01/01/2023 - "Dauricine alleviates cognitive impairment in Alzheimer's disease mice induced by D-galactose and AlCl3 via the Ca2+/CaM pathway." 01/01/2020 - "In this study, we investigated the potential therapeutic effects of dauricine (DAU), a benzyl tetrahydroisoquinoline alkaloid, on AD, and found that DAU administration significantly improved cognitive impairments in 3xTg-AD mice by decreasing Aβ plaques and hyperphosphorylated tau and increasing the hippocampal ATP level. "
2.	Infarction (Infarctions) 01/01/2022 - "We found that dauricine improved the neurological deficits of I/R injury, reduced the infarct volume, and improved the neurological scores. " 03/01/2007 - "The infarct-reducing effects of dauricine may be due, in part, to the inhibition of apoptotic cell death via a mitochondrial pathway in the penumbra." 01/01/2010 - "The infarct-reducing effects of dauricine may be due, in part, to the inhibition of apoptotic cell death via modulation Bcl-2 family protein in the penumbra."
3.	Inflammation (Inflammations) 08/29/2022 - "This study is the first to find that the anti-inflammation mechanism of dauricine mainly occurs through the STAT5-NF-κB pathway and that it might act as a STAT5 inhibitor. " 01/01/2019 - "Collectively, the present study discovers a new biological effect of dauricine in prevention of inflammation, indicating that dauricine can be served as a potential therapeutic agent to treat inflammatory diseases." 01/01/2023 - "Corrigendum: Dauricine attenuates vascular endothelial inflammation through inhibiting NF-κB pathway." 01/01/2021 - "In summary, we concluded that dauricine could alleviate endothelial inflammation by suppressing NF-κB pathway, which might serve as an effective candidate for diseases related with endothelial inflammation." 01/01/2021 - "Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway."
4.	Ischemia 01/01/2007 - "In this study, we investigated the effect of dauricine on the changes of the inflammation process induced by ischemia/reperfusion (I/R). " 08/29/2022 - "Dauricine is an effective agent in anti-inflammation and neuroprotection, but the mechanism by which dauricine acts in ischemia-reperfusion remained unknown. " 05/01/2018 - "Dauricine, isolated from Menispermum dauricum, has been widely used for treatment of various diseases, including cardiac ischemia and inflammation-related diseases. " 01/01/2022 - "In this study, we investigated the effects of dauricine on neuronal injury induced by ischemia-reperfusion and peripheral immune cells after ischemic stroke in mouse model, and we explored the undefined mechanisms of regulating peripheral immune cells through RNA sequencing and various biochemical verification in vitro and in vivo. " 06/01/2007 - "When exploring the pathway, we found that 1 micromol/L dauricine inhibited the [Ca2+]i increase induced by 7.5 nmol/L thapsigargin in either the presence or absence of extracellular Ca2+ and by 1 mmol/L L-glutamate in the presence of extracellular Ca2+. These results suggest that dauricine prevents neuronal loss from ischemia in vitro, which is in accordance with our previous research in vivo. "
5.	Leukemia 03/01/1996 - "To study whether tetrandrine (Tet) and dauricine (Dau) can reduce doxorubicin (Dox) resistance in the harringtonine (Har)-resistant human leukemia cells. " 03/01/1996 - "Reduction of doxorubicin resistance by tetrandrine and dauricine in harringtonine-resistant human leukemia (HL60) cells." 01/01/2020 - "In order to provide more information for their structure activity relationship on P-glycoprotein function, the effects of tetrandrine, isotetrandrine, fangchinoline, berbamine, dauricine, cepharanthine and armepavine on the P-glycoprotein function were compared by using daunorubicin-resistant leukemia MOLT-4 cells in the present study. "

Related Drugs and Biologics

1.	Alkaloids
2.	Therapeutic Uses
3.	1,2,3,4-tetrahydroisoquinoline
4.	Adenosine Triphosphate (ATP)
5.	tetrandrine
6.	Proteins (Proteins, Gene)
7.	Lipopolysaccharides
8.	berbamine (penduline)
9.	cepharanthine
10.	Benzylisoquinolines

Related Therapies and Procedures

1.	Punctures
2.	Ligation
3.	Therapeutics
4.	Intranasal Administration