sophocarpine

04/24/2023 - "Retraction of: Sophocarpine ameliorates cardiac hypertrophy through activation of autophagic responses."
10/01/2020 - "Sophocarpine ameliorates cardiac hypertrophy through activation of autophagic responses."

05/01/2012 - "Based upon our results, we suggest that sophocarpine is an effective agent for treating colonic inflammation."
07/05/2023 - "In conclusion, sophocarpine treatment could alleviate LPS-trigger SIC by repressing oxidative stress, autophagy, inflammation, and apoptosis via TLR-4/NF-κB inhibition and Nrf2/HO-1 signaling pathway activation, implicating the potential of sophocarpine as a new therapeutic approach against SIC."
01/01/2021 - "Sophocarpine markedly decreased the expression of inflammation markers and inhibited microglial activation. "
01/01/2021 - "Sophocarpine has been reported to exert inflammation-regulating effects in various diseases. "
01/01/2018 - "In addition, sophocarpine also attenuated regional and systematic inflammation and further reduced apoptosis of hepatocytes. "

01/01/2005 - "A new method for measurement of (-)-sophocarpine, a candidate therapeutic for viral myocarditis, in plasma: application to a toxicokinetic study in beagle dogs."
06/01/2011 - "Sophocarpine injection (called the Kangke injection) has been demonstrated to have significant antivirus effects against coxsackievirus B3 and therapeutic effects for viral myocarditis in clinical. "
01/01/2005 - "The naturally occurring alkaloid (-)-sophocarpine (SC) has been developed as a novel anti-coxsackieviral agent for potential treatment of viral myocarditis. "
08/01/2014 - "Sophocarpine injection was found to have significant antiviral effects against coxsackievirus B3 and therapeutic effects for viral myocarditis in the clinic. "

08/01/2015 - "[Mechanism of sophocarpine in treating experimental colitis in mice]."
05/01/2012 - "Sophocarpine significantly ameliorated DSS-induced colitis as identified by a reduced disease activity index and wet weight of colons as well as recovery of body weight. "
05/01/2012 - "In conclusion, sophocarpine significantly ameliorated DSS-induced colitis in mice by regulating the pro- and anti-inflammatory cytokine production. "
05/01/2012 - "Experimental colitis was induced in these mice by dissolving 5% DSS in their drinking water for 7 days and sophocarpine (60, 30, and 15 mg/kg of body weight) and sulfasalazine (520 mg/kg) were administered orally once a day for 7 days. "
05/01/2012 - "The natural plant product sophocarpine ameliorates dextran sodium sulfate-induced colitis in mice by regulating cytokine balance."

01/01/2017 - "However, the protective effects of Sophocarpine in T cell-dependent immune hepatitis remained unknown. "
01/01/2017 - "Sophocarpine is the major pharmacologically active compound of the traditional Chinese herbal medicine Radix Sophorae Subprostratae which has been used in treating hepatitis for years in China. "
01/01/2017 - "Sophocarpine Protects Mice from ConA-Induced Hepatitis via Inhibition of the IFN-Gamma/STAT1 Pathway."
01/01/2017 - "The aim of this study was to determine the protective effects and pharmacological mechanisms of Sophocarpine on Concanavalin A (ConA)-induced hepatitis, an experimental model of T cell-mediated liver injury. "