|1.||Mirza, Naheed R: 2 articles (07/2011 - 07/2010)|
|2.||Munro, Gordon: 2 articles (07/2011 - 07/2010)|
|3.||Watt, Heather: 1 article (01/2012)|
|4.||Wergedal, Jon E: 1 article (01/2012)|
|5.||Mohan, Subburaman: 1 article (01/2012)|
|6.||Yu, Hongrun: 1 article (01/2012)|
|7.||Johnson, Patrick J: 1 article (01/2012)|
|8.||Kesavan, Chandrasekhar: 1 article (01/2012)|
|9.||Rae, Mark G: 1 article (07/2011)|
|10.||Erichsen, Helle K: 1 article (07/2011)|
|1.||Myoclonus (Nocturnal Myoclonus)
08/01/1998 - "The same stimulation also induced myoclonic jerks after nine doses of TMPP or PTZ, or after thirteen doses of FG-7142 in 25%, 30% and 20% of animals tested, respectively. "
06/01/1989 - "At 24 hours after the last diazepam dose, 10 of 15 mice had clonic seizures following FG 7142 and four of the remaining five had myoclonic jerks. "
01/01/1989 - "Reversal of ethanol effects on onset of myoclonic jerks, tonic extensor phase, mortality time and percent protection against mortality were compared with not only other anticonvulsant pentobarbital but also with another inverse agonist FG-7142. "
|2.||Post-Traumatic Stress Disorders (PTSD)
01/01/2012 - "This is the first study to document evidence that traumatic events induce lasting consequences on both behavior and skeletal growth, and electric shocks coupled with injection of anxiogenic FG-7142 in young mice can be used as a model to study the effect of PTSD-like symptoms on bone development."
01/01/2012 - "In addition, FG-7142 injection also caused significant reductions of BMC in specific bones such as femur, lumbar vertebra, and tibia at week 3. Strong negative correlations (R(2) = -0.56, P<0.05) and regression (y = 0.2527-0.0037 * x, P<0.01) between freezing behavior and total body BMC in young mice indicated that increased contextual PTSD-like behavior was associated with reduced bone mass acquisition. "
01/01/2000 - "Moreover, FG-7142 may be a useful model of the effects of traumatic stressors on limbic system function in anxiety, especially in view of the recent data in humans implicating right hemispheric function in persisting negative affective states in post-traumatic stress disorder."
11/01/1997 - "Support is provided for the idea that behavioral changes following FG-7142 and predator stress may model anxiety associated with PTSD. "
03/01/2006 - "In mice treated with the three subtype-selective compounds, FG-7142 did not induce seizures. "
03/01/2006 - "Mice were administered compounds twice daily for 4 days and on day 5, 20 h after the final dose, given a dose of FG-7142 (40 mg/kg i.p.) that did not induce seizures in control animals. "
08/01/1998 - "Chemically kindled clonic seizures were observed in 100% of TMPP or FG-7142 and 50% of PTZ treated rats by the thirtieth dosing. "
11/01/1997 - "Both seizures and FG-7142 induce long-term potentiation (LTP) in efferent pathways of the amygdala known to participate in feline defensive behavior. "
04/01/1996 - "The repeated administration of the beta-carboline, FG 7142, to mice leads to 'chemical kindling', i.e., the development of seizures following doses which were initially insufficient to produce convulsive activity. "
08/01/2001 - "In contrast, the administration of a single dose of either antidepressant 40 min before foot shock or FG 7142 injection failed to increase the threshold of excitability of cortical cholinergic neurons. "
11/01/1998 - "Finally, FG 7142 had no detectable effect on the latent inhibition of fear produced by repeatedly presenting the cue alone before conditioning with shock, even though this inhibition, like extinction, was affected by a shift in context. "
05/01/1996 - "A single administration of the anxiogenic beta-carboline FG 7142 (15 mg/kg, i.p.), in contrast, mimicked the effect of foot shock. "
08/01/1993 - "An inverse agonist, the beta-carboline FG 7142, administered in place of inescapable shock, produced an identical pattern of social interaction in a dose-dependent manner. "
07/01/1993 - "3. A brief exposure of rats to CO2 inhalation produced, like foot-shock and FG 7142, a marked increase of 35S-TBPS binding in the cerebral cortex, cerebellum and hippocampus. "
|2.||Ethanol (Ethyl Alcohol)
|3.||GABA-A Receptors (GABA(A) Receptor)
|5.||gamma-Aminobutyric Acid (GABA)
|7.||methyl 6,7- dimethoxy- 4- ethyl- beta- carboline- 3- carboxylate