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CGP 6809
Also Known As:
CGP-6809; ethyl-6-deoxy-3,5-di-O-methyl-6-(3-methyl-3-nitrosoureido)glucofuranoside
Networked:
4
relevant articles (
1
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Urea: 15015
Nitrosourea Compounds: 21
CGP 6809: 4
Nitroso Compounds: 446
Nitrosourea Compounds: 21
CGP 6809: 4
Related Diseases
1.
Neoplasms (Cancer)
01/01/1989 - "
The anti-tumour effect was similar for both application routes; two large bowel cancers responded to treatment with CGP 6809, rectal cancer CXF 158 showed a remission, and the rapidly growing, undifferentiated colonic cancer CXF 280 exhibited a transient no-change.
"
01/01/1987 - "
A phase I study of single i.v. doses of a new sugar containing nitrosourea 6-deoxy-3,5 di-O-methyl 6-(3 methyl-3-nitrosoureido)-alpha-D-glucofuranoside (CGP 6809, EDMN) has been carried out in 47 patients with advanced solid tumors.
"
01/01/1982 - "
Colonic-tumor-bearing animals were subjected to monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.
"
01/01/1982 - "
Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.
"
01/01/1989 - "
Combination therapy using CGP 6809 with cyclophosphamide, 5-fluorouracil, or chlorambucil in the same model led to partial responses of the primary tumor as well as almost total eradication of lung metastases.
"
2.
Rectal Neoplasms (Rectal Cancer)
01/01/1989 - "
The anti-tumour effect was similar for both application routes; two large bowel cancers responded to treatment with CGP 6809, rectal cancer CXF 158 showed a remission, and the rapidly growing, undifferentiated colonic cancer CXF 280 exhibited a transient no-change.
"
3.
Colonic Neoplasms (Colon Cancer)
01/01/1989 - "
The anti-tumour effect was similar for both application routes; two large bowel cancers responded to treatment with CGP 6809, rectal cancer CXF 158 showed a remission, and the rapidly growing, undifferentiated colonic cancer CXF 280 exhibited a transient no-change.
"
4.
Lung Neoplasms (Lung Cancer)
01/01/1989 - "
CGP 6809 is a promising new agent for clinical trials, especially for large bowel and epidermoid lung cancer.
"
5.
Neoplasm Metastasis (Metastasis)
01/01/1989 - "
Combination therapy using CGP 6809 with cyclophosphamide, 5-fluorouracil, or chlorambucil in the same model led to partial responses of the primary tumor as well as almost total eradication of lung metastases.
"
Related Drugs and Biologics
1.
Fluorouracil (Carac)
2.
Tegafur
3.
Sugars
4.
1-ethynyl-2,7-dimethoxynaphthalene
5.
methylamine (methylammonium)
6.
Lomustine (CCNU)
7.
Cyclophosphamide (Cytoxan)
8.
Chlorambucil (Leukeran)
9.
Carmustine (FIVB)
Related Therapies and Procedures
1.
Therapeutics