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2- amino- 8- (beta- ribofuranosyl)imidazo(1,2- a)- 1,3,5- triazin- 4- one

has antiviral activity; RN given refers to (D)-isomer

Also Known As:

5-aza-7-deazaguanosine; ZX 2401; ZX-2401; ZX2401

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Guanosine: 1156
        2-amino-8-(beta-ribofuranosyl)imidazo(1,2-a)-1,3,5-triazin-4-one: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Guanosine: 1156
      - 2-amino-8-(beta-ribofuranosyl)imidazo(1,2-a)-1,3,5-triazin-4-one: 1
  - Ribonucleosides: 49
    - Guanosine: 1156
      - 2-amino-8-(beta-ribofuranosyl)imidazo(1,2-a)-1,3,5-triazin-4-one: 1

Experts

1.	Ali, Shoukath: 1 article (11/2005)
2.	Morrey, John D: 1 article (11/2005)
3.	Ojwang, Joshua O: 1 article (11/2005)
4.	Shimasaki, Craig D: 1 article (11/2005)
5.	Sidwell, Robert W: 1 article (11/2005)
6.	Smee, Donald F: 1 article (11/2005)

Related Diseases

1.	Diarrhea 11/01/2005 - "This compound inhibited yellow fever virus, dengue virus, bovine viral diarrhea virus, banzi virus and West Nile virus with EC50 of 10, 10, 5, 5 and 3 microg/ml, respectively, and the CC50 in these experiments were greater than 1000 microg/ml. The activity of ZX-2401 is comparable to or better than the control drugs in these studies and was not affected by MOI variation. "
2.	Infections 11/01/2005 - "The data described herein suggest that ZX-2401 is a broad-spectrum inhibitor of the RNA viruses, which has merit for development of treatments for the emerging infections caused by the viruses in the Flaviviridae family."