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2- amino- 8- (beta- ribofuranosyl)imidazo(1,2- a)- 1,3,5- triazin- 4- one
has antiviral activity; RN given refers to (D)-isomer
Also Known As:
5-aza-7-deazaguanosine; ZX 2401; ZX-2401; ZX2401
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleosides: 360
Guanosine: 1156
2-amino-8-(beta-ribofuranosyl)imidazo(1,2-a)-1,3,5-triazin-4-one: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Purine Nucleosides: 360
Guanosine: 1156
2-amino-8-(beta-ribofuranosyl)imidazo(1,2-a)-1,3,5-triazin-4-one: 1
Ribonucleosides: 49
Guanosine: 1156
2-amino-8-(beta-ribofuranosyl)imidazo(1,2-a)-1,3,5-triazin-4-one: 1
Experts
1.
Ali, Shoukath
: 1 article (11/2005)
2.
Morrey, John D
: 1 article (11/2005)
3.
Ojwang, Joshua O
: 1 article (11/2005)
4.
Shimasaki, Craig D
: 1 article (11/2005)
5.
Sidwell, Robert W
: 1 article (11/2005)
6.
Smee, Donald F
: 1 article (11/2005)
Related Diseases
1.
Diarrhea
11/01/2005 - "
This compound inhibited yellow fever virus, dengue virus, bovine viral diarrhea virus, banzi virus and West Nile virus with EC50 of 10, 10, 5, 5 and 3 microg/ml, respectively, and the CC50 in these experiments were greater than 1000 microg/ml. The activity of ZX-2401 is comparable to or better than the control drugs in these studies and was not affected by MOI variation.
"
2.
Infections
11/01/2005 - "
The data described herein suggest that ZX-2401 is a broad-spectrum inhibitor of the RNA viruses, which has merit for development of treatments for the emerging infections caused by the viruses in the Flaviviridae family.
"