|1.||Tai, Hsin-Hsiung: 22 articles (12/2011 - 05/2004)|
|2.||Markowitz, Sanford D: 10 articles (02/2015 - 12/2004)|
|3.||Tong, Min: 9 articles (11/2011 - 05/2004)|
|4.||Myung, Seung-Jae: 8 articles (09/2013 - 08/2006)|
|5.||Fink, Stephen P: 7 articles (02/2015 - 06/2009)|
|6.||Yan, Min: 6 articles (06/2014 - 12/2004)|
|7.||Wu, Tong: 5 articles (11/2015 - 01/2008)|
|8.||Han, Chang: 5 articles (11/2015 - 01/2008)|
|9.||Dannenberg, Andrew J: 5 articles (09/2010 - 02/2006)|
|10.||Yang, Peiying: 4 articles (02/2015 - 09/2008)|
11/01/2009 - "Animal breast and colon tumor therapy studies showed that 15-PGDH gene therapy produced a significant delay in 2LMP and LS174T tumor growth. "
11/01/2009 - "The in vitro study showed that Ad-mediated 15-PGDH expression significantly decreased proliferation and migration of cancer cells. "
09/08/2015 - "miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin dehydrogenase (HPGD)."
02/27/2014 - "Forced overexpression of 15-PGDH inhibited HCC cell growth in vitro, whereas knockdown of 15-PGDH enhanced tumor growth parameters. "
09/01/2013 - "15-PGDH represents an independent target for modulation by candidate colon tumor chemopreventive agents."
|2.||Colonic Neoplasms (Colon Cancer)
01/01/2013 - "Recent studies have established the 15-PGDH gene as a colon cancer suppressor. "
02/01/2006 - "This study employed RNAi to specifically knockdown endogenous COX-2 expression in the HT-29 colon cancer cell line, and to observe the apoptotic response as well as 15-hydroxyprostaglandin dehydrogenase (15-PGDH) expression levels. "
01/01/2013 - "Our data suggest that the rs2555639 T allele is associated with increased risk of colon cancer, and that carriers of this risk allele exhibit decreased expression of 15-PGDH in the colon."
01/01/2013 - "In the first two stages, three SNPs (rs1365611, rs6844282 and rs2332897) were statistically significant (p<0.05) in combined analysis of association with risk of colon cancer and of association with 15-PGDH expression, after adjustment for multiple testing. "
01/01/2013 - "We first genotyped 102 single-nucleotide polymorphisms (SNPs) in the 15-PGDH gene, spanning ∼50 kb up and down-stream of the coding region, in 464 colon cancer cases and 393 population controls. "
|3.||Breast Neoplasms (Breast Cancer)
10/01/2014 - "15-Deoxy-Δ12,14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 cells."
03/01/2012 - "However, the detailed role of 15-hydroxyprostaglandin dehydrogenase (HPGD), the key enzyme degrading prostaglandin E(2) , remains unclear in breast cancer. "
03/01/2012 - "15-Hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells."
08/01/2006 - "Our results indicate for the first time that 15-PGDH may be a novel tumor suppressor gene in breast cancer, and suggest that this enzyme can modulate the ER pathway."
08/01/2006 - "Analysis of 15-PGDH expression revealed low levels in 40% of primary breast tumors and identified a correlation between 15-PGDH and ER expression. "
05/22/2006 - "These studies have also presented compelling evidence for a direct link, through the expression of the prostaglandin degrading enzyme 15-PGDH, between early apocrine lesions and pure apocrine carcinomas. "
03/14/2012 - "Reduction of 15-PGDH is associated with carcinogenesis and development of gastric carcinoma. "
03/14/2012 - "15-PGDH is reduced and induces apoptosis and cell cycle arrest in gastric carcinoma."
12/31/2008 - "Promoter hypermethylation of 15-PGDH gene was not detected in carcinomas, with only a negligible expression of the enzyme. "
12/31/2008 - "We investigated the expression of 15-PGDH in 28 cases of advanced gastric carcinomas by Western blot analysis and also the relation between its expression and the gene promoter methylation. "
|5.||Stomach Neoplasms (Stomach Cancer)
03/14/2012 - "Human gastric cancer cell line SGC-7901 was transfected with 15-PGDH expression plasmids. "
03/14/2012 - "The association between expression of 15-PGDH and various clinicopathological parameters in gastric cancer was evaluated. "
03/14/2012 - "The relationship between gastric cancer, gastric precancerous state and 15-PGDH expression was determined. "
03/14/2012 - "To investigate the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human gastric cancer and it's mechanism in apoptosis and cell cycle arrest. "
10/15/2010 - "Stable silencing of 15-PGDH in gastric cancer cells also enhanced cell cycle entry in vitro. "
|3.||Small Interfering RNA (siRNA)
|8.||Messenger RNA (mRNA)
|9.||Cyclooxygenase 2 (Cyclooxygenase-2)
|10.||Proteins (Proteins, Gene)
|2.||Heterologous Transplantation (Xenotransplantation)
|5.||Drug Therapy (Chemotherapy)