15-hydroxyprostaglandin dehydrogenase

Subscribe to Selected New Research on 15-hydroxyprostaglandin dehydrogenase

55 relevant articles (0 outcomes, 8 trials/studies) found for this Bio-Agent

Description: catalyzes reversibly the oxidation of 11 alpha, 15-dihydroxy-9-ketoprost-13-enoate to 11 alpha-9,15-diketoprost-13-enoate in presence of NAD

Also Known As:

15-HPDnase; 15-PGDH; 15-PGDH, type-I; 15-hydroxy-PG dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NAD+); 15-ketoprostaglandin reductase; NAD+-dependent 15-hydroxyprostaglandin dehydrogenase; prostaglandin-15-hydroxydehydrogenase; type-I 15-PGDH

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1

Enzymes: 24340

Oxidoreductases: 6825

Alcohol Oxidoreductases

Hydroxyprostaglandin Dehydrogenases: 2

15-hydroxyprostaglandin dehydrogenase: 55

Experts

1.	Tai, Hsin-Hsiung: 15 articles (09/2008 - 05/2004)
2.	Tong, Min: 9 articles (01/2008 - 05/2004)
3.	Ding, Yunfei: 4 articles (05/2007 - 01/2005)
4.	O'Kelly, James: 2 articles (09/2008 - 08/2006)
5.	Koeffler, H Phillip: 2 articles (09/2008 - 08/2006)
6.	Wolf, Ido: 2 articles (09/2008 - 08/2006)
7.	Yan, Min: 2 articles (07/2008 - 12/2004)
8.	Lawrence, Earl: 2 articles (07/2008 - 12/2004)
9.	Markowitz, Sanford D: 2 articles (07/2008 - 12/2004)
10.	Challis, John R G: 2 articles (04/2007 - 06/2004)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2008 - "15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice." 05/01/2007 - "These results suggest that tumor suppressive action of these agents may, in part, be related to their ability to induce 15-PGDH expression." 05/01/2007 - "However, cells stably over-expressing 15-PGDH generated tumors faster than those control cells" 08/08/2006 - "We first show that 15-PGDH gene knockout induces a marked 7.6-fold increase in colon tumors arising in the Min (multiple intestinal neoplasia) mouse model" 08/01/2006 - "Transfection assays showed that transient up-regulation of 15-PGDH levels in MDA-MB-231 cells resulted in a decreased clonal growth, and stable up-regulation significantly decreased the ability of these cells to form tumors in athymic mice" Get all the results and reference details, order at left...
2.	Colonic Neoplasms (Colon Cancer) 02/01/2006 - "This study employed RNAi to specifically knockdown endogenous COX-2 expression in the HT-29 colon cancer cell line, and to observe the apoptotic response as well as 15-hydroxyprostaglandin dehydrogenase (15-PGDH) expression levels" 11/15/2008 - "Finally, in human colon cancers, elevated HDAC expression correlated with down-regulation of 15-PGDH" 08/08/2006 - "15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers" 12/14/2004 - "We find that 15-PGDH transcript and protein are both highly expressed by normal colonic epithelia but are nearly undetectable in colon cancers" 12/14/2004 - "We report that, in addition to inducing expression of COX-2, colon cancers further target the prostaglandin biogenesis pathway by ubiquitously abrogating expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme that physiologically antagonizes COX-2" Get all the results and reference details, order at left...
3.	Carcinoma (Carcinomatosis) 05/22/2006 - "These studies have also presented compelling evidence for a direct link, through the expression of the prostaglandin degrading enzyme 15-PGDH, between early apocrine lesions and pure apocrine carcinomas" 02/01/2007 - "Expression of 15-hydroxyprostaglandin dehydrogenase, a COX-2 antagonist and tumour suppressor, is not altered in gastric carcinomas." 02/04/2005 - "By contrast, the expression of 15-PGDH is decreased in several colorectal carcinoma cell lines and in other human malignancies such as breast and lung carcinomas" 08/08/2006 - "Furthermore, 15-PGDH gene knockout abrogates the normal resistance of C57BL/6J mice to colon tumor induction by the carcinogen azoxymethane (AOM), conferring susceptibility to AOM-induced adenomas and carcinomas in situ" Get all the results and reference details, order at left...
4.	Adenocarcinoma 05/01/2007 - "A549 human lung adenocarcinoma cells were used as a model system to study the role of 15-PGDH in lung tumorigenesis" 11/01/2006 - "Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells." 03/01/2005 - "Dexamethasone induced the expression of 15-PGDH in a time- and concentration-dependent manner in A549 human lung adenocarcinoma cells" 11/01/2006 - "Human lung adenocarcinoma cells, A549, possess the capacity of expressing both cyclooxygenase-2 (COX-2) and NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH)" 09/14/2006 - "Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells." Get all the results and reference details, order at left...
5.	Ureteral Obstruction 02/01/1985 - "Deficiency in 15-hydroxyprostaglandin dehydrogenase activity after unilateral ureteral obstruction of the dog kidney." 02/01/1985 - "In the present study, metabolism of prostaglandins (PGs) by 15-hydroxyprostaglandin dehydrogenase (15-OH PGDH) was investigated in dog kidneys with ureteral obstruction" 04/01/2004 - "Ureteral obstruction is associated with increased prostanoid synthesis via cyclooxygenase induction; however, prostaglandin degradation mediated by 15-hydroxyprostaglandin dehydrogenase (PGDH) has not been evaluated in the ureter" 04/01/2004 - "Suppression of 15-hydroxyprostaglandin dehydrogenase messenger RNA concentration, protein expression, and enzymatic activity during human ureteral obstruction." 09/30/1985 - "Acute ureteral obstruction increased cyclooxygenase, thromboxane and prostacyclin synthases and NAD+-linked 15-hydroxyprostaglandin dehydrogenase activities in rat kidney" Get all the results and reference details, order at left...
38 Diseases and 55 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Prostaglandins
3.	Oxidoreductases
4.	A-Form DNA (A-DNA)
5.	Galectin 1 (LGALS1)
6.	Annexin A1
7.	Transcription Factors (Transcription Factor)
8.	Lysophospholipase (Phospholipase B)
9.	Cytochrome P-450 Enzyme System (Cytochrome P450)
10.	Coenzyme A (CoA)
55 Drugs and Important Bio-Agents and 41 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Chemoprevention
2 Therapies and Procedures and 3 more articles analyzed in the Research Interface, order at left...

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License details >>

Price:

$490.00 access via web interface, 1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m", 1 year subscription

Proceed to Checkout >>