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B-HT 958
RN given refers to parent cpd
Also Known As:
2-amino-6-(p-chlorobenzyl)-4H-5,6,7,8-tetrahydrothiazolo (5,4-d)azepine; B HT-958; B-HT 958 dihydrochloride
Networked:
3
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azepines: 11
B-HT 958: 3
Related Diseases
1.
Hypotension (Low Blood Pressure)
02/01/1986 - "
Sulpiride 10 micrograms and 50 micrograms i.c.v. caused inhibition of B-HT 958 hypotension and bradycardia similar to that of intravenous sulpiride.
"
02/01/1986 - "
This combination however had a significantly greater effect in inhibiting B-HT 958 hypotension than had idazoxan 1000 micrograms kg-1 alone, and almost completely blocked the B-HT 958-induced fall in plasma noradrenaline concentration.
"
02/01/1986 - "
A combination of idazoxan 1000 micrograms kg-1 i.v. and sulpiride 300 micrograms kg-1 i.v. did not cause further significant inhibition of B-HT 958 hypotension and bradycardia compared with sulpiride 300 micrograms kg-1 i.v. alone.
"
2.
Bradycardia
11/13/1984 - "
(i) In the dog, intracisternally injected B-HT 958 (300 micrograms/kg) abolished the reflex bradycardia facilitated by the alpha 2-agonist B-HT 920 (10 micrograms/kg i.ci.).
"
02/01/1986 - "
Sulpiride 10 micrograms and 50 micrograms i.c.v. caused inhibition of B-HT 958 hypotension and bradycardia similar to that of intravenous sulpiride.
"
01/13/1984 - "
Also in contrast to clonidine, B-HT 958 did not induce vagal baroreflex bradycardia in anaesthetized dogs with blocked beta-adrenoceptors following intracisternal (30 micrograms/kg as well as 3 mg/kg) injection.
"
02/01/1986 - "
A combination of idazoxan 1000 micrograms kg-1 i.v. and sulpiride 300 micrograms kg-1 i.v. did not cause further significant inhibition of B-HT 958 hypotension and bradycardia compared with sulpiride 300 micrograms kg-1 i.v. alone.
"
Related Drugs and Biologics
1.
Idazoxan
2.
Norepinephrine (Noradrenaline)
3.
Sulpiride (neogama)
4.
Adrenergic Receptors (Adrenergic Receptor)
5.
Clonidine (ST 155)
6.
talipexole