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leucinal

RN given refers to (S)-isomer

Also Known As:

2-amino-4-methyl-1-pentanal; L-leucinal; Pentanal, 2-amino-4-methyl-, (S)-

Networked: 29 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Branched-Chain Amino Acids: 2289
    - Leucine: 6718
      - leucinal: 29
  - Essential Amino Acids: 1152
    - Leucine: 6718
      - leucinal: 29

Experts

1.	Wójcik, C: 2 articles (03/2004 - 07/2001)
2.	Ganapathy, Ashwinkumar Subramenium: 1 article (01/2022)
3.	Koltun, Walter: 1 article (01/2022)
4.	Ma, Thomas: 1 article (01/2022)
5.	Nighot, Meghali: 1 article (01/2022)
6.	Nighot, Prashant: 1 article (01/2022)
7.	Saha, Kushal: 1 article (01/2022)
8.	Singh, Vikash: 1 article (01/2022)
9.	Suchanec, Eric: 1 article (01/2022)
10.	Verma, Aayush: 1 article (01/2022)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 11/18/2006 - "Our study demonstrated that proteasome inhibitor MG132 (carbobenzoxy-L-leucyle-L-leucyl-L-leucinal) was a potent death-inducing agent for PC3 prostate cancer cells. " 11/19/2020 - "In this study, we showed that the proteasome inhibitors bortezomib (BZM) and carbobenzoxy-L-leucyl-L-leucyl-L-leucinal (MG132) impaired MTX-induced ICD in prostate cancer cells, as measured using ICD biomarkers and dendritic cell activation in vitro. "
2.	Leukemia 10/01/2000 - "In this study, we demonstrate that cell-permeable proteasome inhibitors, lactacystin, benzyloxycarbonyl(Z)-leucyl-leucyl-leucinal (ZLLLal; MG-132) and 4-hydroxy-5-iodo-3-nitrophenylacetyl-leucyl-leucyl-leucine vinyl sulfone (NLVS), induce apoptosis abundantly in p53-defective leukemic cell lines CCRF-CEM, U937 and K562 as well as in myelogenic and lymphatic leukemic cells obtained from adult individuals with relapsed acute leukemias. " 09/15/2000 - "We have investigated the effects of the proteasome inhibitors carbobenzoxyl-L-leucyl-L-leucyl-L-leucinal (MG132) and N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal (LLnL) on apoptosis and NF-kappaB activation induced by etoposide, using a human leukemia cell line (U937) and leukemia blasts freshly isolated from patients with acute leukemia. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 12/01/2005 - "In the present study, we investigated whether the cell-permeable proteasome inhibitor MG132 (carbobenzoxyl-L-leucyl-L-leucyl-L-leucinal) reduced the growth of a human pancreatic cancer cell line through induction of apoptosis in vitro. "
4.	Myocardial Infarction 08/01/2018 - "The aim of the present study was to investigate the impact of carbobenzoxy-Leu-Leu-leucinal (MG-132) on myocardial remodeling in rats with myocardial infarction (MI) and investigate the possible underlying mechanisms. "
5.	Hypertrophy 05/01/2001 - "1. In the present study, we investigated the potential of the proteasome inhibitor N-benzyloxycarbonyl-Ile-Glu(O-t-Bu)-Ala-leucinal (PSI) to prevent vascular hypertrophy induced by deoxycorticosterone acetate (DOCA) and salt in rats. "

Related Drugs and Biologics

1.	Proteasome Inhibitors
2.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde
3.	leucylleucine (Leu-Leu)
4.	Salts
5.	Desoxycorticosterone Acetate (DOCA)
6.	Desoxycorticosterone (Deoxycorticosterone)
7.	Acetates (Acetic Acid Esters)
8.	lactacystin
9.	Biomarkers (Surrogate Marker)
10.	Bortezomib (Velcade)

Related Therapies and Procedures

1.	Surgical Instruments (Clip)