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lanthionine ketimine

structure given in first source

Also Known As:

2H-1,4-Thiazine-3,5-dicarboxylic acid, 3,6-dihydro-

Networked: 15 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfur Amino Acids: 221
    - lanthionine ketimine: 15
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Sulfur Amino Acids: 221
    - lanthionine ketimine: 15

Experts

1.	Hensley, Kenneth: 12 articles (01/2022 - 06/2011)
2.	Feinstein, Douglas L: 4 articles (01/2022 - 07/2015)
3.	Harris-White, Marni E: 4 articles (01/2016 - 10/2013)
4.	Eslami, Pirooz: 3 articles (01/2016 - 10/2013)
5.	Johnson, Ming F: 3 articles (01/2016 - 10/2013)
6.	Venkova, Kalina: 3 articles (12/2015 - 06/2011)
7.	Boullerne, Anne I: 2 articles (01/2022 - 01/2019)
8.	Denton, Travis T: 2 articles (01/2022 - 01/2015)
9.	Dupree, Jeffrey L: 2 articles (01/2022 - 07/2015)
10.	Kalinin, Sergey: 2 articles (01/2022 - 01/2019)

Related Diseases

1.	Glioma (Gliomas) 12/01/2015 - "We now report that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimine (LK), stimulates autophagy in RG2 glioma and SH-SY5Y neuroblastoma cells at concentrations within or below pharmacological levels reported in previous mouse studies. " 01/01/2015 - "The review will explore possible endogenous functions of lanthionine metabolites and will discuss the therapeutic potential of lanthionine ketimine derivatives for mitigating diverse neurological conditions including Alzheimer׳s disease, stroke, motor neuron disease, and glioma. "
2.	Alzheimer Disease (Alzheimer's Disease) 10/01/2013 - "A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease." 10/01/2013 - "Lanthionine ketimine and its synthetic derivatives have recently demonstrated neurotrophic, neuroprotective, and antineuroinflammatory properties in vitro through a proposed mechanism involving the microtubule-associated protein collapsin response mediator protein 2. Therefore, studies were undertaken to test the effects of a bioavailable LK ester in the 3 × Tg-AD mouse model of Alzheimer disease. " 12/01/2015 - "To exemplify one such novel therapeutic entity, data is presented that the antioxidant and neurotrophic agent lanthionine ketimine-ethyl ester (LKE) affects autophagy pathway proteins including beclin-1 in the 3xTg-AD model of Alzheimer's disease where the compound has been shown to reduce pathological features and cognitive dysfunction. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 11/30/2018 - "Preclinical studies in the search for treatments for several neurodegenerative diseases have identified lanthionine ketimine (LK) and its monoethyl ester derivative (LKE) as potential candidates. "
4.	Neuroblastoma 12/01/2015 - "We now report that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimine (LK), stimulates autophagy in RG2 glioma and SH-SY5Y neuroblastoma cells at concentrations within or below pharmacological levels reported in previous mouse studies. "
5.	Cognitive Dysfunction 01/01/2016 - "Lanthionine ketimine ethyl ester, which we have shown previously to modulate autophagy markers and alleviate pathology and slow cognitive decline in the 3 × TgAD mouse model, spared cognition and pathology after central fluid percussion injury through a mechanism involving autophagy modulation." 10/01/2013 - "Lanthionine ketimine ester treatment substantially diminished cognitive decline and brain amyloid-β (Aβ) peptide deposition and phospho-Tau accumulation in 3 × Tg-AD mice and also reduced the density of Iba1-positive microglia. " 12/01/2015 - "To exemplify one such novel therapeutic entity, data is presented that the antioxidant and neurotrophic agent lanthionine ketimine-ethyl ester (LKE) affects autophagy pathway proteins including beclin-1 in the 3xTg-AD model of Alzheimer's disease where the compound has been shown to reduce pathological features and cognitive dysfunction. "

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