SS-A antigen (Ro antigen)

RefSeq NM_003141(TRIM21 human)

Also Known As:

Ro antigen; Ro autoantigen; Ro ribonucleoprotein; Ro-SSA antigen; Ro52 antigen; Ro60 antigen; SS A antigen; Sjogren syndrome type A antigen; TRIM21 protein, human; TRIM21 protein, mouse; tripartite motif-containing 21 protein, human

Networked: 71 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - RNA-Binding Proteins: 3262
      - Ribonucleoproteins: 1286
        SS-A antigen: 71
  - Nucleoproteins: 1870
    - RNA-Binding Proteins: 3262
      - Ribonucleoproteins: 1286
        SS-A antigen: 71

Experts

1.	Boutjdir, Mohamed: 2 articles (11/2016 - 07/2015)
2.	Capecchi, Pier-Leopoldo: 2 articles (11/2016 - 07/2015)
3.	Chahine, Mohamed: 2 articles (11/2016 - 07/2015)
4.	Fabris, Frank: 2 articles (11/2016 - 07/2015)
5.	Jiang, Xian-Cheng: 2 articles (11/2016 - 07/2015)
6.	Laghi-Pasini, Franco: 2 articles (11/2016 - 07/2015)
7.	Lazzerini, Pietro-Enea: 2 articles (11/2016 - 07/2015)
8.	Qu, Yongxia: 2 articles (11/2016 - 07/2015)
9.	Yue, Yuankun: 2 articles (11/2016 - 07/2015)
10.	Kurien, Biji T: 2 articles (11/2012 - 12/2005)

Related Diseases

1.	Heart Block 11/01/1987 - "The possible relationship between the location of Ro (SS-A) antigen, anti-Ro (SS-A) antibody, and heart block is discussed." 09/01/1993 - "On SDS-immunoblot, sera from 91% of the heart block group mothers who had antibodies to SS-A/Ro but not to SS-B/La recognized at least 1 SS-A/Ro antigen, with significantly greater reactivity against the 52-kd component. " 09/01/1993 - "Although there was no profile of anti-SS-A/Ro response unique to the mothers of children with heart block or cutaneous manifestations of neonatal lupus, only 1% of the healthy infants were born to mothers with antibodies directed to both the 52-kd SS-A/Ro and 48-kd SS-B/La antigens and not to the 60-kd SS-A/Ro antigen. "
2.	Congenital heart block 04/01/1997 - "Cardiac expression of 52beta, an alternative transcript of the congenital heart block-associated 52-kd SS-A/Ro autoantigen, is maximal during fetal development." 03/01/2016 - "Particularly, anti-p200 antibodies against a finer specificity of the Ro/SSA antigen, have been associated with congenital heart block. " 01/01/2006 - "The objective of this study was to identify putative Ro52/60-kDa Ro/SSA antigen (Ro60) epitopes associated with neonatal lupus and congenital heart block. " 02/01/1998 - "Studies of Ro ribonucleoprotein are important in rheumatology, since anti-Ro antibodies are probably involved in the pathogenesis of congenital heart block and subacute cutaneous lupus erythematosus. " 01/01/2006 - "The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction disturbances, mainly congenital heart block. "
3.	Cutaneous Lupus Erythematosus 08/15/2013 - "Studies analyzing how particular drug classes affect Ro/SS-A antigen expression may be useful in identifying mechanisms of action in drug-induced subacute cutaneous lupus erythematosus. " 06/01/2006 - "Apoptosis and redistribution of the Ro autoantigen in Balb/c mouse like in subacute cutaneous lupus erythematosus." 08/01/1985 - "We have shown that SS-A/Ro antigen is a normal component of tissues that may be affected in neonatal lupus (fetal myocardium, neonatal epidermis) and in subacute cutaneous lupus erythematosus (adult epidermis)." 08/15/2013 - "Taxanes are proposed to exacerbate or induce subacute cutaneous lupus erythematosus in immunogenetically predisposed patients by stabilizing microtubules and affecting Ro/SS-A antigen (Ro52) expression. " 10/01/2012 - "Subacute cutaneous lupus erythematosus (SCLE) is characterized by nonscarring, photodistributed, annular or papulosquamous plaques with antibodies to Ro/SS-A antigen. "
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/01/1999 - "The Ro ribonucleoprotein complex (Ro RNP) was initially described as an autoimmune target in human diseases such as systemic lupus erythematosus and Sjögren's syndrome. " 09/01/1994 - "To compare patterns of Ro autoantigen recognition in primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). " 10/01/1995 - "This study provides evidence that CMV infection induced 60 KD/Ro antigen expression on the surface of human keratinocytes, suggesting that CMV may play a role in development of skin lesions in systemic lupus erythematosus (SLE)." 11/01/2012 - "The Ro ribonucleoprotein particle, targeted in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS), includes Ro60 (SSA) and La (SSA) autoantigens. " 12/01/2010 - "The 60-kDa Ro/SS-A antigen for autoantibodies can be found in sera from systemic lupus erythematosus (SLE) patients. "
5.	Neonatal Systemic lupus erythematosus 08/01/1985 - "We have shown that SS-A/Ro antigen is a normal component of tissues that may be affected in neonatal lupus (fetal myocardium, neonatal epidermis) and in subacute cutaneous lupus erythematosus (adult epidermis)." 08/01/1996 - "The recognition of human 60-kDa Ro ribonucleoprotein particles by antibodies associated with cutaneous lupus and neonatal lupus." 05/01/1989 - "The presence of antibodies directed against the Ro (SS-A) antigen is the strongest risk factor for the neonatal lupus syndrome. " 01/01/2006 - "The objective of this study was to identify putative Ro52/60-kDa Ro/SSA antigen (Ro60) epitopes associated with neonatal lupus and congenital heart block. " 01/01/2006 - "The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction disturbances, mainly congenital heart block. "

Related Drugs and Biologics

1.	Antibodies
2.	Autoantibodies
3.	Proteins (Proteins, Gene)
4.	SS-A antibodies
5.	Epitopes
6.	SS-B Antigen
7.	Antigens
8.	Calreticulin
9.	Peptides (Polypeptides)
10.	Autoantigens