|1.||Akinaga, S: 5 articles (12/2001 - 08/2000)|
|2.||Soga, S: 3 articles (12/2001 - 09/2000)|
|3.||Neckers, L M: 3 articles (12/2001 - 09/2000)|
|4.||Akinaga, Shiro: 2 articles (01/2013 - 10/2003)|
|5.||Shiotsu, Yukimasa: 2 articles (01/2013 - 10/2003)|
|6.||Soga, Shiro: 2 articles (01/2013 - 10/2003)|
|7.||Lee, Chung Soo: 2 articles (11/2012 - 01/2012)|
|8.||Myung, Soon Chul: 2 articles (11/2012 - 01/2012)|
|9.||Kim, Wonyong: 2 articles (11/2012 - 01/2012)|
|10.||Rowlands, Martin G: 2 articles (12/2011 - 09/2010)|
02/01/2007 - "Dipalmitoylation of radicicol results in improved efficacy against tumor growth and angiogenesis in vivo."
11/01/2013 - "Finally, the review also deals with radicicol, which is a nanomolar inhibitor of the chaperone Hsp90, whose suppression leads to a combinatorial block of cancer-causing pathways. "
12/22/2008 - "The RAL radicicol is a nanomolar inhibitor of the chaperone Hsp90, whose repression leads to a combinatorial blockade of cancer-causing pathways. "
02/01/2007 - "Here we report the effects of radicicol, a microbial angiogenesis inhibitor that we previously identified using the chorioallantoic membrane assay, and its novel analog, 14,16-dipalmitoyl-radicicol, on tumor angiogenesis and growth. "
11/15/2006 - "The finding that radicicol can inhibit at least two different antitumoral drug targets in human, and interferes with drugs currently used in cancer treatment, could have implications in cancer therapy."
05/23/2008 - "In this work we show that the level of Sgt1 is increased in HEp-2 cells exposed to heat shock or radicicol. "
09/01/2014 - "In cells treated with both radicicol and VER155008, compared to cells treated with radicicol-alone, cell viability further decreased and the percentage of dead cells further increased, with a parallel decrease of the protein levels of heat shock cognate 70, Akt and survivin. "
10/01/2009 - "In this study, we tested the effect of 17-allylaminogeldanamycin and radicicol, drugs targeting the heat shock protein-90 (HSP-90) chaperone protein and displaying antimyeloma activity, on the expression of NKG2D and DNAM-1 ligands in human myeloma cell lines. "
09/12/2003 - "Inhibition of Hsp90 by geldanamycin, radicicol, cisplatin, and novobiocin induced a significant acceleration of detergent- and hypotonic shock-induced cell lysis. "
04/01/2002 - "Geldanamycin (GA), herbimycin A and radicicol bind heat-shock protein-90 (Hsp90) and destabilize its client proteins including v-Src, Bcr-Abl, Raf-1, ErbB2, some growth factor receptors and steroid receptors. "
01/01/2012 - "These results suggest that radicicol may potentiate the apoptotic effect of TRAIL on ovarian carcinoma cell lines by increasing the activation of the caspase-8- and Bid-dependent pathway and the mitochondria-mediated apoptotic pathway, leading to caspase activation. "
01/01/2012 - "To assess the ability of an inhibitor of Hsp90 inhibitor radicicol to promote apoptosis, we investigated the effect of radicicol on TRAIL-induced apoptosis in the human epithelial ovarian carcinoma cell lines OVCAR-3 and SK-OV-3. "
01/09/1998 - "In K-ras-transformed, rat epithelial, and K-ras-activated, human pancreatic carcinoma cell lines, radicicol inhibited K-Ras-induced hyperphosphorylation of Erk2. "
11/20/1997 - "Radicicol was found to inhibit the growth of several other oncogene-transformed cell lines and human carcinoma cell lines and to revert their cell morphology to be flat. "
01/01/2012 - "Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins."
|5.||Breast Neoplasms (Breast Cancer)
10/01/2003 - "Radicicol oxime showed potent antitumor activity against ER negative/ErbB2 overexpressing breast cancer and Bcr-Abl expressing CML. "
12/01/2001 - "KF58333 showed potent antiproliferative activity against all breast cancer cell lines tested in vitro, and was more potent than its stereoisomer KF58332. "
12/01/2001 - "Interestingly, KF58333, but not KF58332, showed significant in vivo antitumor activity accompanied by induction of apoptosis in KPL-4 human breast cancer xenografts. "
07/01/2001 - "We found that interaction of the Hsp90-binding drugs geldanamycin and radicicol with the chaperone destabilizes these hormone receptors in a ligand-independent manner, leading to profound and prolonged depletion of their levels in breast cancer cells cultured in vitro. "
12/01/2001 - "A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts."
|4.||Proteins (Proteins, Gene)
|5.||Heat-Shock Proteins (Heat-Shock Protein)
|7.||Protein-Tyrosine Kinases (Tyrosine Kinase)
|8.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|9.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|1.||Heterologous Transplantation (Xenotransplantation)