endo-N-acetylneuraminidase

coliphage enzyme breaks E coli capsular polysaccharide down to oligosaccharides; cleaves alpha-2,8-linked polysialic acid

Also Known As:

endo NE; endo NF; endo-N-acetylneuraminidase E; endo-N-acetylneuraminidase F; endo-N-acylneuraminidase; endosialidase

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Glycoside Hydrolases: 871
      - Neuraminidase: 4879
        endo-N-acetylneuraminidase: 10

Experts

1.	Luzio, J Paul: 2 articles (07/2010 - 07/2005)
2.	Taylor, Peter W: 2 articles (07/2010 - 07/2005)
3.	Finne, Jukka: 1 article (10/2021)
4.	Jokilammi, Anne: 1 article (10/2021)
5.	Korja, Miikka: 1 article (10/2021)
6.	Lehti, Timo A: 1 article (10/2021)
7.	Lilie, Hauke: 1 article (10/2021)
8.	Pajunen, Maria I: 1 article (10/2021)
9.	Vettenranta, Kim: 1 article (10/2021)
10.	Appleyard, Caroline B: 1 article (01/2018)

Related Diseases

1.	Infections 03/01/2010 - "Adding endosialidase to cells infected with K1-ind phage increased fitness in serum by enhancing productive infection after adsorption. " 07/01/2010 - "Administration of capsule-selective endosialidase E minimizes upregulation of organ gene expression induced by experimental systemic infection with Escherichia coli K1." 07/01/2005 - "The aim of this study was to investigate the effect of single doses of the capsule depolymerizing enzyme endosialidase E (endoE) on the course of systemic infection due to Escherichia coli K1 strains in neonatal rats. "
2.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/01/2018 - "Noncatalytic Endosialidase Enables Surface Capture of Small-Cell Lung Cancer Cells Utilizing Strong Dendrimer-Mediated Enzyme-Glycoprotein Interactions." 11/01/1994 - "We have studied the site of synthesis and the cell surface re-expression of polysialic acid in a clonal subline of small cell lung carcinoma using the monoclonal antibody 735 and bacteriophage endosialidase, both specific reagents for polysialic acid. "
3.	Neuroblastoma 10/01/2021 - "We found that the binding of a noncatalytic endosialidase to polysialic acid causes internalization of the complex from the surface of neuroblastoma kSK-N-SH cells, a subline of SK-N-SH, and leads to a complete relocalization of polysialic acid to the intracellular compartment. " 07/15/1987 - "After treatment with endosialidase, the diffusely migrating neuroblastoma material was resolved into 3 discrete bands of 120, 140 and 180 kDa. In Ewing extract, high-molecular-weight NCAM species were also detected with a 3-band pattern more reminiscent of mature brain. "
4.	Neoplasms (Cancer) 01/01/2018 - "Targeting polysialic acid-abundant cancers using oncolytic adenoviruses with fibers fused to active bacteriophage borne endosialidase." 10/01/2021 - "The results demonstrate that noncatalytic endosialidase induces a quantitative removal and cellular uptake of polysialic acid from the cell surface which, by conjugation with diphtheria toxin fragment, can be exploited for the selective elimination of polysialic acid-containing tumor cells."
5.	Leukemia 04/01/1996 - "The presence of authentic alpha 2, 8-polysialic acid on the basophilic leukemia and breast cancer proteins was confirmed by the elimination of anti-polysialic acid antibody staining after treatment with the alpha 2, 8-polysialic acid-specific endo-N-acetylneuraminidase. "

Related Drugs and Biologics

1.	Enzymes
2.	Capsules (Microcapsules)
3.	polysialic acid
4.	Dendrimers (Dendrons)
5.	Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)
6.	Proteins (Proteins, Gene)
7.	Indicators and Reagents (Reagents)
8.	Glycoproteins (Glycoprotein)
9.	Diphtheria Toxin
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Aftercare (After-Treatment)