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piriprost
structure given in first source
Also Known As:
6,9-deepoxy-6,9-(phenylimino)-delta (6,8)pgI1; 6,9-desepoxy-6,9-(phenylimino)-delta-(6,8)prostaglandin I1; U 60,257; U 60257; U 60257B; U-60,257; U-60257; Cyclopenta(b)pyrrole-2-pentanoic acid, 1,4,5,6-tetrahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-phenyl-, (4R-(4alpha(1E,3S*),5beta))-
Networked:
16
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Lipids: 114793
Fatty Acids: 27405
Unsaturated Fatty Acids: 8236
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins I: 108
Epoprostenol: 4670
piriprost: 16
Biological Factors: 2472
Inflammation Mediators: 1113
Autacoids: 276
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins I: 108
Epoprostenol: 4670
piriprost: 16
Related Diseases
1.
Asthma (Bronchial Asthma)
10/01/1986 - "
On the assumption that inhaled piriprost was bioavailable in the airways, this study casts doubt on any theory of a pivotal role for leukotrienes in the pathogenesis of acute exercise and allergen induced airway bronchoconstriction in asthma.
"
10/01/1986 - "
We have investigated the effects of a leukotriene synthesis inhibitor, piriprost (U-60, 257) administered by inhalation on allergen and exercise induced bronchoconstriction in 12 subjects with allergic asthma.
"
10/01/1986 - "
Effect of inhaled piriprost (U-60, 257) a novel leukotriene inhibitor, on allergen and exercise induced bronchoconstriction in asthma.
"
07/01/1997 - "
Many of these medications appear to be effective in the treatment of asthma (BAYX-1005; MK-0591; MK-886; AA-681; A-64077; ZD-2138; U-60257; FR-110302; BI-6239; A-78773; ABT-761; L-746530; L-699333; ZM-230487).
"
2.
Glioma (Gliomas)
06/01/1990 - "
The results of the monolayer studies showed potent and dose dependent inhibitory effects on the proliferation of glioma cells (IC50/one week treatment/of AA-863: 9.0 microM, IC50 of U-60,257: 40.0 microM).
"
06/01/1990 - "
Effects of the 5-lipoxygenase inhibitors AA-863 and U-60,257 on human glioma cell lines.
"
06/01/1990 - "
The effects of two specific 5-lipoxygenase inhibitors AA-863 and U-60,257 (piriprost) on the growth of two human glioma cell lines, U-343 MGa and U-251 MG were investigated.
"
3.
Leukemia
05/01/1987 - "
Our previous observation that piriprost is only a very weak inhibitor of the solubilized LTC synthase of rat basophil leukemia cells was extended to similar enzyme preparations derived from the mouse mast cells (IC50 1.5 mM).
"
05/01/1987 - "
Experiments on the mode of action of piriprost (U-60,257), an inhibitor of leukotriene formation in cloned mouse mast cells and in rat basophil leukemia cells.
"
05/01/1982 - "
On the other hand, U-60,257 inhibited glutathione S-transferase activity of rat basophil leukemia cells (ID50, 37 microM), suggesting that this compound may inhibit the last step in LTC biosynthesis.
"
05/01/1987 - "
We studied the effect of piriprost, an inhibitor of sulfidopeptide leukotriene (LT) formation, on the generation of the known products of the 5-lipoxygenase pathway of arachidonate metabolism in calcium ionophore A23187-challenged rat basophil leukemia cells and cloned, growth factor-dependent, mouse mast cells.
"
02/01/1986 - "
Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine, and synergism between diethylcarbamazine and piriprost, a 5-lipoxygenase inhibitor.
"
4.
Necrosis
06/01/1990 - "
At higher doses (AA-863: 10.0-30.0 microM, U-60,257: 30.0-90.0 microM) the experiments with spheroids failed to demonstrate a further inhibitory effect on spheroid volume, probably attributed to phenomena such as swelling of cells, dissociation of spheroid structure and development of necrosis.
"
01/01/1986 - "
Inhibition of RTC arachidonic acid metabolism by methylprednisolone, indomethacin, ibuprofen, and piriprost significantly inhibited RTC necrosis induced by TSST-1 and LPS or lipid A by 33-62%.
"
5.
Bronchial Hyperreactivity
10/01/1985 - "
U-60,257 inhibits O3-induced bronchial hyperreactivity in the guinea pig.
"
Related Drugs and Biologics
1.
L 746530
2.
atreleuton
3.
ZM 230487
4.
L 699333
5.
A 78773
6.
MK 0591
7.
ICI D2138
8.
FR 110302
9.
zileuton (Zyflo)
10.
MK-886
Related Therapies and Procedures
1.
Ligation