rosaprostol

structure given in first source; RN given refers to parent cpd without isomeric designation

Also Known As:

9-hydroxy-19,20-bisnorprostanoic acid; 9-hydroxy-19,20-bisnorprostanoic acid, monosodium salt; 9-hydroxy-19,20-bisnorprostanoic acid, monosodium salt, (1S-(1alpha,2beta,5beta))-isomer; IBI-C83; Cyclopentaneheptanoic acid, 2-hexyl-5-hydroxy-

Networked: 8 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Prostanoic Acids
    - rosaprostol: 8

Related Diseases

1.	Hemorrhage 01/01/1991 - "A double blind randomized placebo-controlled study demonstrates the protective efficacy of rosaprostol on aspirin-induced gastrointestinal bleeding in man."
2.	Peptic Ulcer (Peptic Ulcers) 01/01/1987 - "In nearly all trials natural prostaglandin E2 as well as the synthetic prostaglandin analogues arbaprostil, misoprostol, enprostil, rioprostil, trimoprostil, and rosaprostol accelerated the healing of peptic ulcers compared with placebo. "
3.	Joint Diseases (Joint Disease) 01/01/1988 - "Pre-treatment with rosaprostol (2 g given 30 min before the start of the trial) prevented the drop in pH. Twenty subjects with chronic joint diseases were divided into two groups in a cross-over double-blind randomized experimental design. "
4.	Duodenal Ulcer (Curling's Ulcer) 06/30/1987 - "The results obtained with the combined treatment Rosaprostol + anti-H2 in 10 patients with duodenal ulcer previously treated with insufficient results with anti-H2 drugs are described (in comparison with other 10 patients under the same conditions treated with anti-H2 alone). " 06/30/1987 - "[Treatment of duodenal ulcer with rosaprostol in patients resistant to treatment with anti-H2]." 08/01/1984 - "The effects of 9-hydroxy-19,20-bis norprostanoic acid (rosaprostol, IBI), a new prostaglandin analogue, on gastric secretion and gastrin release were studied in 15 patients with duodenal ulcer. "
5.	Necrosis 01/01/1988 - "It was found that: (i) 40% ethanol damaged the duodenum, with blood extravasation, inflammation and necrosis of the mucosa, (ii) rosaprostol significantly protected the mucosa 3 min after 40% ethanol, and (iii) the damage became worse after 3 h when placebo was given, whereas it was reduced after 1 h when PG was administered. "

Related Drugs and Biologics

1.	Aspirin (Acetylsalicylic Acid)
2.	Synthetic Prostaglandins (Prostaglandin Analogues)
3.	Rioprostil
4.	Enprostil
5.	Misoprostol (Cytotec)
6.	Dinoprostone (PGE2)
7.	Arbaprostil
8.	trimoprostil
9.	Astemizole
10.	Theophylline (Theon)

Related Therapies and Procedures

1.	Therapeutics