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pentazirinocyclodiphosphathiazene (SOAZ)
structure given in first source
Also Known As:
SOAZ
; 1,3,3,5,5-pentazridino-1-thia-2,4,6-triaza-3,5-diphosphorine-1-oxide; pentakis(aziridino)thiatriazadiphosphorine oxide; pentazirino-cyclo-diphosphathiazene; 1H-1,2,4,6,3,5-Thiatriazadiphosphorine, 1,3,3,5,5-pentakis(1-aziridinyl)-3,3,5,5-tetrahydro-, 1-oxide
Networked:
7
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azirines
pentazirinocyclodiphosphathiazene: 7
Experts
1.
Almeida, C
: 1 article (10/2011)
2.
Barros, A
: 1 article (10/2011)
3.
Cunha, M
: 1 article (10/2011)
4.
Ferraz, L
: 1 article (10/2011)
5.
Silva, J
: 1 article (10/2011)
6.
Sousa, M
: 1 article (10/2011)
Related Diseases
1.
Leukemia L1210
12/01/1986 - "
SOAz showed marked antitumor effect against early-stage L1210 leukemia, and was also effective against advanced-stage L1210 leukemia.
"
10/01/1982 - "
In contrast to cyclophosphamide, SOAz was active against B16 melanoma and Meth A, and demonstrated high activity against a subline of L1210 leukemia resistant to cyclophosphamide.
"
10/01/1982 - "
The optimal treatment regimens of SOAz (i.p.) gave 262% and 134% increase in life span (ILS) in mice with P388 leukemia and L1210 leukemia implanted intraperitoneally, respectively, and 239% ILS in rats with Yoshida sarcoma of which 86% survived for 60 d after intraperitoneal tumor implantation.
"
2.
Neoplasms (Cancer)
05/01/1984 - "
Eleven patients with advanced cancer were treated with SOAz, the first aziridino substituted inorganic heterocyclic compound to undergo phase I clinical trials.
"
10/01/1982 - "
1,3,3,5,5-Pentaziridino-1-thia-2,4,6-triaza-3,5-diphosphorine-1-oxide (SOAz), a new antitumor agent, was evaluated for antitumor activity against various mouse- and rat-tumor systems.
"
10/01/1982 - "
The optimal treatment regimens of SOAz (i.p.) gave 262% and 134% increase in life span (ILS) in mice with P388 leukemia and L1210 leukemia implanted intraperitoneally, respectively, and 239% ILS in rats with Yoshida sarcoma of which 86% survived for 60 d after intraperitoneal tumor implantation.
"
3.
Leukemia P388
10/01/1982 - "
The optimal treatment regimens of SOAz (i.p.) gave 262% and 134% increase in life span (ILS) in mice with P388 leukemia and L1210 leukemia implanted intraperitoneally, respectively, and 239% ILS in rats with Yoshida sarcoma of which 86% survived for 60 d after intraperitoneal tumor implantation.
"
12/01/1986 - "
SOAz was found to have similar activity to carbazilquinone, cyclophosphamide or mitomycin C on P388 leukemia.
"
4.
Azoospermia
10/01/2011 - "
Testicular spermatozoa were collected from 18 men after testicular biopsy during assisted reproductive treatments: five presented oligozoospermia, four congenital bilateral absence of the vas deferens (CBAVD), five secondary obstructive azoospermia (sOAZ) and four hypospermatogenesis.
"
5.
Small Cell Carcinoma
06/01/1986 - "
We investigated the mode of action on DNA of three different compounds, 1,3,3,5,5-pentakis (1-aziridinyl)-1 lambda 6,2,4,6,3 lambda 5,5 lambda 5-thiatriazadiphosphorine -1-oxide (SOAz), trans-1,3-bis(1-aziridinyl)-1,3,5,5-tetrakis (methylamino)-2,4,6,1 lambda 5,3 lambda 5,5 lambda 5-triazatriphosphorine (AZP), and 1,trans-5-bis(1-azaridinyl)-gem-1,3,3'-cis-5,7,7'-hexakis (methylamino)-2,4,6,8,1 lambda 5,3 lambda 5,5 lambda 5,7 lambda 5 -tetraazatetraphosophocine (AZM), of this group in the Ehrlich ascites tumor cell line (EAT) and a human small cell carcinoma cell line.
"
Related Drugs and Biologics
1.
Cyclophosphamide (Cytoxan)
2.
Caspase 3 (Caspase-3)
3.
Therapeutic Uses
4.
Mitomycin (Mitomycin-C)
5.
Heterocyclic Compounds (Compounds, Heterocyclic)
6.
DNA (Deoxyribonucleic Acid)
7.
Carbazilquinone (Carboquone)
8.
Antineoplastic Agents (Antineoplastics)
9.
Antigen-Antibody Complex (Immune Complex)