deoxyuridine phosphorylase

the enzyme participates the the pathways of pyrimidine ribonucleosides degradation and salvage; mammalian enzyme also accepts 2'-deoxyuridine.

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Experimental Liver Neoplasms 03/01/1980 - "On the basis of this definition and studies with GPT in nonfocused cytosol preparations, we conclude that FdUrd is cleaved to 5-fluorouracil by uridine-deoxyuridine phosphorylase activity in Ehrlich ascites cells and in Novikoff hepatoma cells, and by dThd phosphorylases in mouse liver, in normal human leukocytes, and in HeLa (S3) cells."
2.	Ascites 03/01/1980 - "On the basis of this definition and studies with GPT in nonfocused cytosol preparations, we conclude that FdUrd is cleaved to 5-fluorouracil by uridine-deoxyuridine phosphorylase activity in Ehrlich ascites cells and in Novikoff hepatoma cells, and by dThd phosphorylases in mouse liver, in normal human leukocytes, and in HeLa (S3) cells."
3.	Neoplasms (Cancer) 05/01/1982 - "Six candidate irreversible inhibitors of uridine--deoxyuridine phosphorylase (EC 2.4.2.3) from Walker 256 rat tumor were synthesized. "

1.	Uridine
2.	Phosphorylases (Glucan Phosphorylase)
3.	Fluorouracil (Carac)