01/01/1994 - "Picenadol in a large multicenter dental pain study."
06/01/1988 - "Both picenadol and codeine were significantly more effective than placebo in reducing pain intensity (mean sum of pain intensity difference scores: picenadol 5.21, codeine 5.19, and placebo 2.82) and increasing total relief (mean total pain relief: picenadol 10.21, codeine 11.07, and placebo 6.96). "
01/01/1994 - "Single oral doses of picenadol 15 and 30 mg, an opioid agonist-antagonist, were compared with codeine 30 and 90 mg and placebo in 408 patients with moderate or severe pain from third molar extraction in a randomized, double-blind, parallel study. "
01/01/1994 - "Picenadol 22 mg was estimated to be equianalgesic to codeine 60 mg, and picenadol 30 mg was safe in this dental pain model."
01/01/1994 - "To estimate the analgesic dose of picenadol hydrochloride equal to codeine 60 mg in a dental pain model. "
10/01/1993 - "Intramuscular picenadol in patients with postoperative pain."
06/01/1988 - "A double-blind, parallel study was conducted to evaluate the analgesic effect and safety of a single 25 mg oral dose of picenadol, a centrally acting analgesic, and to compare it with a 60 mg dose of codeine and a placebo in patients with postoperative pain. "
06/01/1988 - "Analgesic effect of picenadol, codeine, and placebo in patients with postoperative pain."
10/15/1983 - "Hospitalized post-cesarean section patients with postoperative pain were blindly given an intramuscular dose of picenadol, 25 mg, meperidine, 100 mg, or placebo. "
10/01/1993 - "1. The analgesic efficacy and safety of a single 50 mg intramuscular dose of rac-picenadol, a centrally acting agonist-antagonist opioid analgesic, were compared with pethidine (meperidine) 100 mg and placebo in 60 patients with moderate to severe postoperative pain using hourly pain intensity and relief measurements for up to 6 h following injection of the study medications. "
08/01/1985 - "Effects of picenadol (LY150720) and its stereoisomers on electric shock titration in the squirrel monkey."
11/27/1984 - "Quantitative analysis of the interaction between the agonist and antagonist isomers of picenadol (LY150720) on electric shock titration in the squirrel monkey."
08/01/1985 - "Shock intensity increases produced by picenadol occurred over a broader dose range than with either the d-isomer or morphine. "
08/01/1985 - "Picenadol (0.1-17.5 mg/kg), the d-isomer (0.3-3.0 mg/kg) and morphine (0.3-5.6 mg/kg) produced dose-related increases in the intensity at which monkeys maintained the shock without decreasing responding in the presence of shock. "
08/01/1985 - "Increases in shock intensity produced by picenadol, the d-isomer and morphine were blocked by naloxone (0.001-1.0 mg/kg), although the effects of picenadol were less susceptible to antagonism. "
|5.||Speech Disorders (Cluttering)
|1.||Codeine (Codeine Phosphate)
|5.||Morphine (MS Contin)
|1.||Cesarean Section (Caesarean Section)