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bassianolide

cyclodepsipeptide from mycelia of Beauveria bassiana; inhibits isotonic contractions induced by acetylcholine

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - bassianolide: 6
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - bassianolide: 6

Experts

1.	Pedrini, Nicolás: 2 articles (10/2020 - 06/2015)
2.	Espinosa-Artiles, Patricia: 2 articles (05/2009 - 01/2009)
3.	Molnár, István: 2 articles (05/2009 - 01/2009)
4.	Xu, Yuquan: 2 articles (05/2009 - 01/2009)
5.	Baldiviezo, Linda Vanesa: 1 article (10/2020)
6.	Cardozo, Rubén Marino: 1 article (10/2020)
7.	Gentile, Alberto: 1 article (10/2020)
8.	Mannino, María Constanza: 1 article (10/2020)
9.	Nieva, Lucía Beatriz: 1 article (10/2020)
10.	Santana, Marianela: 1 article (10/2020)

Related Diseases

1.	Infections 04/01/2018 - "This is the first study to report the infection process and the interaction of fungal mediated cyclicdepsipeptide compound (bassianolide) from L. " 05/01/2009 - "Comparative infection assays against three selected insect hosts established bassianolide as a highly significant virulence factor of B. " 10/12/2020 - "However, Bb-C001 showed a higher expression than GHA of the bassianolide synthetase gene (BbbslS) during infection, and similar levels of the beauvericin synthetase gene (BbbeaS). " 06/01/2015 - "In this study, quantitative reverse transcription real-time PCR (qRT-PCR) was used to measure the transcript levels within the insect fungal pathogen Beauveria bassiana, that encode for the synthetase enzymes of the secondary metabolites tenellin (BbtenS), beauvericin (BbbeaS) and bassianolide (BbbslS) during the infection of Triatoma infestans, a Chagas disease insect vector. "
2.	Chagas Disease (American Trypanosomiasis) 06/01/2015 - "In this study, quantitative reverse transcription real-time PCR (qRT-PCR) was used to measure the transcript levels within the insect fungal pathogen Beauveria bassiana, that encode for the synthetase enzymes of the secondary metabolites tenellin (BbtenS), beauvericin (BbbeaS) and bassianolide (BbbslS) during the infection of Triatoma infestans, a Chagas disease insect vector. "
3.	Neoplasms (Cancer) 12/01/2016 - "The cytotoxicity of the (-)-bassianolide was evaluated against five human tumor cells, and the results showed that the (-)-bassianolide displayed significant cytotoxicity against A549, SK-OV-3, HepG2, HCT-15, MCF-7 and MDA-MB 231 cell lines with IC50 values of 7.24, 8.44, 15.39, 6.40, 11.42 and 3.98 μg/mL respectively. " 12/01/2016 - "One of the cyclodepsipeptides, (-)-bassianolide, represents rich pharmacophores with diverse biological activities including potential cytotoxicity to various cancer cells. " 01/26/2009 - "Fungal cyclooligomer depsipeptides such as beauvericin, bassianolide, and enniatins display antibiotic, antifungal, insecticidal, broad-spectrum cancer cell antiproliferative, and cell migration inhibitory activities. "
4.	Breast Neoplasms (Breast Cancer) 12/01/2016 - "Synthesis and antitumor activity of (-)-bassianolide in MDA-MB 231 breast cancer cells through cell cycle arrest."

Related Drugs and Biologics

1.	Ligases (Synthetase)
2.	beauvericin
3.	Enzymes
4.	tenellin
5.	Depsipeptides
6.	Virulence Factors (Pathogenicity Factors)
7.	Anti-Bacterial Agents (Antibiotics)
8.	enniatins
9.	beauvericin synthetase