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N(7)-hydroxyethylguanine

Also Known As:

7-(2-hydroxyethyl)guanine; N7-(2-hydroxyethyl)guanine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        N(7)-hydroxyethylguanine: 2

Experts

1.	Brown, Karen: 1 article (02/2007)
2.	Farmer, Peter B: 1 article (02/2007)
3.	Jones, Donald J L: 1 article (02/2007)
4.	Lamb, John H: 1 article (02/2007)
5.	Marsden, Debbie A: 1 article (02/2007)
6.	Tompkins, Elaine M: 1 article (02/2007)
7.	Bodell, W J: 1 article (10/2001)
8.	Giannini, D D: 1 article (10/2001)
9.	Hassenbusch, S: 1 article (10/2001)
10.	Levin, V A: 1 article (10/2001)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2007 - "EO is classed by the IARC as carcinogenic to humans and reacts with DNA, primarily forming N7-(2-hydroxyethyl)guanine adducts (N7-HEG), which can be used as biomarkers of exposure and potential cancer risk. "
2.	Brain Neoplasms (Brain Tumor) 10/01/2001 - "Levels of N7-(2-hydroxyethyl)guanine as a molecular dosimeter of drug delivery to human brain tumors." 10/01/2001 - "The level of N7-(2-hydroxyethyl)guanine (N7-HOEtG), one of the DNA alkylation products formed by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) treatment, was measured in human brain tumor samples by high performance liquid chromatography with electrochemical detection. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Biomarkers (Surrogate Marker)
3.	Carmustine (FIVB)

Related Therapies and Procedures

1.	Radiation Dosimeters