|1.||Li, Zhiyu: 3 articles (09/2015 - 01/2009)|
|2.||Guo, Qinglong: 3 articles (09/2015 - 01/2009)|
|3.||Lu, Na: 3 articles (09/2015 - 06/2011)|
|4.||You, Qidong: 3 articles (01/2014 - 01/2009)|
|5.||Berardi, Francesco: 3 articles (09/2011 - 12/2009)|
|6.||Perrone, Roberto: 3 articles (09/2011 - 12/2009)|
|7.||Abate, Carmen: 3 articles (09/2011 - 12/2009)|
|8.||Najajreh, Yousef: 3 articles (06/2007 - 11/2002)|
|9.||Gibson, Dan: 3 articles (06/2007 - 11/2002)|
|10.||Supuran, Claudiu T: 2 articles (09/2015 - 08/2009)|
07/30/1988 - "A controlled trial was performed to evaluate the efficacy of piperazine dihydrochloride in a new granular formulation (Ascarex D) against naturally occurring infections with Ascaris suum, Oesophagostomum dentatum and O quadrispinulatum. "
06/28/1963 - "THE EFFICACY OF TRICHLOROPHENOL PIPERAZINE AGAINST MIXED INFECTIONS OF ANCYLOSTOMA DUODENALE AND NECATOR AMERICANUS, AND ASCARIS LUMBRICOIDES."
07/01/2003 - "In the present study, one of these compounds, 7-O-[4-methyl piperazine-1-(2-acetyl)]-2H-1-benzopyran-2-one (2), which has shown promising macrofilaricidal action against rodent filariid Litomosoides carinii in cotton rats, was evaluated against infection with Brugia malayi in Mastomys coucha and jird (Meriones unguiculatus). "
10/01/1966 - "[Trial of a mixture of piperazine and pryvinium in the treatment of ascaris and oxyuris infections]."
11/17/1956 - "Whipworm infections trial of four piperazine compounds."
|2.||Alzheimer Disease (Alzheimer's Disease)
02/01/2009 - "Synthesis and enzymatic evaluation of new series of N(4)-substituted piperazine naphthamide derivatives as BACE-1 inhibitors for the treatment of Alzheimer's disease are reported."
08/01/2006 - "Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease."
03/01/2015 - "Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease."
01/01/2012 - "In this study, benzothiazole-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheimer's disease, with the aim of obtaining new and potent anti-Alzheimer agents. "
11/01/2001 - "The N1-p-hydroxylphenyl substituted compound 22 and the methoxyphenyl substituted compound missing the piperazine ring 12 were identified as promising candidates for the further development of an improved treatment of tuberculosis. "
11/01/2009 - "Both isoprenyl PCU tetra-amine derivatives and N-decyl piperazine PCU (9a) were highly active against the XDR 194 strain of tuberculosis with MICs in the range of 0.63-3.02 microM. "
01/01/2007 - "Hydrophilic cyclic secondary amines were substituted to the core scaffold and a benzyl piperazine substitution was found to be most effective in achieving improved solubility and potent anti-tuberculosis activity. "
09/01/2014 - "In search of potential therapeutics for tuberculosis, we describe here the synthesis and in vitro antitubercular activity of a novel series of thiazolone piperazine tetrazole derivatives. "
03/31/1962 - "An improved piperazine preparation in the treatment of ascariasis."
07/01/1982 - "Piperazine administration decreased the prevalence of ascariasis to 33.8% at the end of the study but growth remained unaltered. "
02/01/1966 - "Field trials with piperazine derivatives against ascariasis in pigs and calves."
10/01/2006 - "Piperazine (diethylenediamine) is an anthelmintic widely used against animal and bird ascariasis. "
12/01/1973 - "[Technical piperazine hexahydrate in ascariasis of chickens]."
|5.||Memory Disorders (Memory Loss)
02/16/2001 - "We have demonstrated that FK960 [N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate], a novel putative anti-dementia drug of piperazine derivative, ameliorates memory deficits in a variety of animal models of dementia in rats and monkeys, and also augments long-term potentiation (LTP) in the mossy fiber-CA3 pathway in guinea-pig hippocampal slices. "
06/01/1998 - "Our previous studies have demonstrated that FK960 (FR59960; N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate), a novel antidementia piperazine derivative, exerts beneficial effects on memory deficits in various animal models of amnesia in rats [M. "
03/01/1997 - "Our previous studies demonstrated that FK960 [N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate], a novel antidementia piperazine derivative, exerts beneficial effects on memory deficits in various rodent models of amnesia, through activation of the somatostatin neuronal system. "
|1.||N-(4-acetyl-1-piperazinyl) -4-fluorobenzamide monohydrate
|8.||Dopamine Agonists (Dopamine Agonist)
|10.||Excipients (Suspending Agents)
|1.||Chinese Traditional Medicine (Traditional Chinese Medicine)
|2.||Hormone Replacement Therapy (Therapy, Hormone Replacement)
|4.||Drug Therapy (Chemotherapy)