CYVADIC protocol

04/30/1989 - "Still today, after 10 years of use, the CYVADIC regimen is very widely employed as a standard treatment for recurrent or metastatic soft tissue sarcomas, although the original positive results have been confirmed only by a few authors. "
07/01/2004 - "Efficacy of adjuvant CYVADIC chemotherapy in early-stage uterine sarcomas: results of long-term follow-up."
05/01/1984 - "Cyvadic in advanced soft tissue sarcoma: a randomized study comparing two schedules. "
01/01/2015 - "The CYVADIC regimen as a combination chemotherapy treatment option for advanced soft tissue sarcomas originating from the non-extremities."
12/01/2007 - "MAID and CYVADIC are two effective chemotherapy regimens for adult soft tissue sarcoma. "

11/01/1991 - "For localized disease, in a randomized trial of the EORTC including 374 evaluable patients with resectable tumors with a mean follow-up of 44 months, the interest of 8 Cyvadic as adjuvant chemotherapy after adequate locoregional treatment (surgery with or without radiotherapy) was demonstrated only for locoregional relapse free survival but no for metastatic disease free survival or overall survival.(ABSTRACT TRUNCATED AT 250 WORDS)"
03/01/2009 - "The recurrent tumors showed remarkable reduction after the two courses of CYVADIC chemotherapy. "
09/01/1999 - "A recurrent tumor showed remarkable reduction after three courses of CYVADIC chemotherapy. "
08/01/1997 - "The tumor recurred at the duodenum 7 years later and was completely removed following neoadjuvant CYVADIC. "
08/01/1997 - "The tumor was removed with the right kidney and ureter and a part of the vena cava after 2 courses of CYVADIC. "

03/01/2007 - "Resection was done for each metastasis, and postoperative radiotherapy (66 Gy) and chemotherapy (CYVADIC) were done. "
06/01/1994 - "In contrast, distant metastases occurred with similar frequency in both arms, 32% for CYVADIC versus 36% for control patients (P = .42), and overall survival rates were not significantly different at 63% versus 56% (P = .64). "
09/01/1990 - "Chemotherapy (CyVADic regimen) was attempted in three patients with metastases and one patient with a huge local recurrence, but proved to be ineffective. "
03/01/1980 - "One patient had a complete response and showed no evidence of disease 23 months after treatment with surgery and combination chemotherapy (CYVADIC); she also had maturation of established metastases. "
07/01/2002 - "The patient developed a local relapse and pulmonary metastasis of fibrosarcoma one month postoperatively and died two month later without any response to chemotherapy (CYVADIC) and radiotherapy. "

09/01/1999 - "[Remission due to CYVADIC chemotherapy of primary leiomyosarcoma derived from mesentelium of the sigmoid colon: a case report]."
02/01/1990 - "We treated a patient with a large gastric epithelioid leiomyosarcoma with a combination of surgery and the CYVADIC regime. "
08/01/1989 - "[Successful CYVADIC combination chemotherapy of metastatic pulmonary lesions involving a mediastinal leiomyosarcoma--a case report]."
09/01/1994 - "Uterine myxoid leiomyosarcoma and CYVADIC-etoposide therapy."
09/01/1999 - "We report a case of leiomyosarcoma of mesenthelium origin, which was successfully treated with a combination of cyclophosphamide, vincristine, adriamycin and dacarbazine (CYVADIC). "

01/01/1980 - "CYVADIC toxicity was predominantly limited to myelosuppression, vomiting, fever of unknown origin, and neuropathy. "
10/01/1987 - "A total of 237 cycles of this modified CYVADIC protocol resulted in tolerable toxicity (except nausea and vomiting) and therapeutic results comparable to the original protocol (6/22 complete remissions and 6/22 partial remissions in sarcomas; 1/5 partial remission in mesotheliomas). "